Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 166 |
Chain | Residue |
A | HIS119 |
A | HIS123 |
A | HIS129 |
A | WAY169 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN A 167 |
Chain | Residue |
A | HIS69 |
A | HIS84 |
A | HIS97 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CA A 168 |
Chain | Residue |
A | PRO78 |
A | SER79 |
A | GLY80 |
A | LEU81 |
A | ASP99 |
A | GLU102 |
A | ASP76 |
A | GLY77 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE WAY A 169 |
Chain | Residue |
A | GLY80 |
A | LEU81 |
A | LEU82 |
A | LEU115 |
A | VAL116 |
A | HIS119 |
A | HIS123 |
A | HIS129 |
A | PRO139 |
A | TYR141 |
A | ZN166 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
Chain | Residue | Details |
A | VAL116-LEU125 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU120 | |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
Chain | Residue | Details |
A | ASP25 | |
A | ASP99 | |
A | ASP100 | |
A | GLU102 | |
A | ASP59 | |
A | ASP76 | |
A | GLY77 | |
A | SER79 | |
A | LEU81 | |
A | ASN91 | |
A | GLY93 | |
A | ASP95 | |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
Chain | Residue | Details |
A | HIS69 | |
A | ASP71 | |
A | HIS84 | |
A | HIS97 | |
A | HIS119 | |
A | HIS123 | |
A | HIS129 | |
A | MET137 | |
Chain | Residue | Details |
A | ASN14 | |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN49 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU120 | |
A | MET137 | |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU120 | |