1FLJ
CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003009 | biological_process | skeletal muscle contraction |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030017 | cellular_component | sarcomere |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0033993 | biological_process | response to lipid |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0044320 | biological_process | cellular response to leptin stimulus |
| A | 0045471 | biological_process | response to ethanol |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0097305 | biological_process | response to alcohol |
| A | 0097421 | biological_process | liver regeneration |
| A | 1903427 | biological_process | negative regulation of reactive oxygen species biosynthetic process |
| A | 1903751 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 262 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | HOH312 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH A 1183 |
| Chain | Residue |
| A | SER182 |
| A | CYS183 |
| A | ARG189 |
| A | HOH270 |
| A | HOH422 |
| A | HOH440 |
| A | HOH460 |
| A | HOH465 |
| A | PRO53 |
| A | GLU156 |
| A | HIS178 |
| A | PHE179 |
| A | ASP180 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GSH A 1188 |
| Chain | Residue |
| A | GLY171 |
| A | ALA187 |
| A | CYS188 |
| A | GLU214 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgvkYaaELHLV |
| Chain | Residue | Details |
| A | SER105-VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Region: {"description":"Involved in proton transfer","evidences":[{"source":"UniProtKB","id":"P07451","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11024467","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P07450","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-glutathionyl cysteine","evidences":[{"source":"PubMed","id":"11024467","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ca2 |
| Chain | Residue | Details |
| A | THR199 | |
| A | LYS64 |
