Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR CHAIN C OF INHIBITOR |
| Chain | Residue |
| A | SER10 |
| A | PHE108 |
| A | ILE110 |
| A | TYR198 |
| A | LYS224 |
| A | ASP228 |
| A | GLY230 |
| A | THR231 |
| A | THR232 |
| A | ARG235 |
| A | THR329 |
| A | GLY11 |
| A | HOH490 |
| C | HOH9 |
| C | HOH10 |
| C | HOH11 |
| C | HOH12 |
| C | HOH13 |
| A | ASP32 |
| A | GLY34 |
| A | SER35 |
| A | PRO70 |
| A | TYR71 |
| A | THR72 |
| A | GLN73 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR CHAIN D OF INHIBITOR |
| Chain | Residue |
| B | SER10 |
| B | GLY11 |
| B | ASP32 |
| B | GLY34 |
| B | SER35 |
| B | PRO70 |
| B | TYR71 |
| B | THR72 |
| B | GLN73 |
| B | PHE108 |
| B | TYR198 |
| B | ASP228 |
| B | GLY230 |
| B | THR231 |
| B | THR232 |
| B | ARG235 |
| B | SER328 |
| B | HOH440 |
| B | HOH449 |
| B | HOH498 |
| B | HOH566 |
| B | HOH583 |
| D | HOH9 |
| D | HOH10 |
| D | HOH11 |
| D | HOH13 |
| D | HOH14 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE29-VAL40 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA42 | |
| A | LYS238 | |
| B | ALA42 | |
| B | LYS238 | |
| Chain | Residue | Details |
| A | LYS75 | |
| B | ASP228 | |
| B | LEU234 | |
| B | ILE248 | |
| B | LYS249 | |
| B | LYS256 | |
| A | LYS224 | |
| A | ASP228 | |
| A | LEU234 | |
| A | ILE248 | |
| A | LYS249 | |
| A | LYS256 | |
| B | LYS75 | |
| B | LYS224 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE102 | |
| A | LEU121 | |
| A | GLY172 | |
| A | GLN303 | |
| B | ILE102 | |
| B | LEU121 | |
| B | GLY172 | |
| B | GLN303 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | THR231 | |
| A | ASP228 | |
| A | SER35 | |
| A | ASP32 | |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | THR231 | |
| B | ASP228 | |
| B | ASP32 | |
| B | THR33 | |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP228 | |
| A | ASP32 | |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP228 | |
| B | ASP32 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | THR231 | |
| B | ASP228 | |
| B | SER35 | |
| B | ASP32 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP228 | |
| A | SER229 | |
| A | ASP32 | |
| A | THR33 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP228 | |
| B | SER229 | |
| B | ASP32 | |
| B | THR33 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP228 | |
| A | SER35 | |
| A | ASP32 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP228 | |
| B | SER35 | |
| B | ASP32 | |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP228 | |
| A | SER35 | |
| A | TYR71 | |
| A | ASP32 | |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP228 | |
| B | SER35 | |
| B | TYR71 | |
| B | ASP32 | |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | THR231 | |
| A | ASP228 | |
| A | ASP32 | |
| A | THR33 | |
