1FJM

Protein serine/threonine phosphatase-1 (alpha isoform, type 1) complexed with microcystin-LR toxin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0001111	biological_process	RNA polymerase II promoter clearance
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005977	biological_process	glycogen metabolic process
A	0006446	biological_process	regulation of translational initiation
A	0006470	biological_process	protein dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0032922	biological_process	circadian regulation of gene expression
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0042752	biological_process	regulation of circadian rhythm
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043558	biological_process	regulation of translational initiation in response to stress
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048511	biological_process	rhythmic process
A	0051301	biological_process	cell division
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0072542	molecular_function	protein phosphatase activator activity
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A	1901567	molecular_function	fatty acid derivative binding
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0001111	biological_process	RNA polymerase II promoter clearance
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005977	biological_process	glycogen metabolic process
B	0006446	biological_process	regulation of translational initiation
B	0006470	biological_process	protein dephosphorylation
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0032922	biological_process	circadian regulation of gene expression
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
B	0042752	biological_process	regulation of circadian rhythm
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0043558	biological_process	regulation of translational initiation in response to stress
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048511	biological_process	rhythmic process
B	0051301	biological_process	cell division
B	0072357	cellular_component	PTW/PP1 phosphatase complex
B	0072542	molecular_function	protein phosphatase activator activity
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B	1901567	molecular_function	fatty acid derivative binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 400

Chain	Residue
A	ASP92
A	ASN124
A	HIS173
A	HIS248
A	MN401
A	HOH402

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 401

Chain	Residue
A	MN400
A	HOH402
M	HOH8
A	ASP64
A	HIS66
A	ASP92

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 399

Chain	Residue
A	PHE257
A	ARG261
A	CYS291

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 400

Chain	Residue
B	ASP92
B	ASN124
B	HIS173
B	HIS248
B	MN401
B	HOH402

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 401

Chain	Residue
B	ASP64
B	HIS66
B	ASP92
B	MN400
B	HOH402
N	HOH128

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME B 399

Chain	Residue
B	ILE169
B	LEU289
B	MET290
B	CYS291
B	HOH536

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62136","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62136","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
A	ASP95
A	HIS125

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
B	ASP95
B	HIS125

---