1FJ2
Crystal structure of the human acyl protein thioesterase 1 at 1.5 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002084 | biological_process | protein depalmitoylation |
| A | 0004620 | molecular_function | phospholipase activity |
| A | 0004622 | molecular_function | lysophospholipase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008474 | molecular_function | palmitoyl-(protein) hydrolase activity |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016298 | molecular_function | lipase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0042997 | biological_process | negative regulation of Golgi to plasma membrane protein transport |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1905336 | biological_process | negative regulation of aggrephagy |
| B | 0002084 | biological_process | protein depalmitoylation |
| B | 0004620 | molecular_function | phospholipase activity |
| B | 0004622 | molecular_function | lysophospholipase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0008474 | molecular_function | palmitoyl-(protein) hydrolase activity |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016298 | molecular_function | lipase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0042997 | biological_process | negative regulation of Golgi to plasma membrane protein transport |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1905336 | biological_process | negative regulation of aggrephagy |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 801 |
| Chain | Residue |
| A | LEU25 |
| A | SER114 |
| A | GLN115 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 802 |
| Chain | Residue |
| B | LEU25 |
| B | SER114 |
| B | GLN115 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 803 |
| Chain | Residue |
| B | ARG13 |
| B | THR16 |
| B | HIS43 |
| B | ILE224 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 804 |
| Chain | Residue |
| A | THR16 |
| A | PRO223 |
| A | ILE224 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 805 |
| Chain | Residue |
| B | ALA11 |
| B | HOH1067 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 806 |
| Chain | Residue |
| A | ALA11 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 807 |
| Chain | Residue |
| A | HOH905 |
| A | HOH974 |
| B | THR28 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 808 |
| Chain | Residue |
| A | THR28 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 810 |
| Chain | Residue |
| A | GLY200 |
| B | GLN207 |
| B | GLN208 |
| site_id | ACA |
| Number of Residues | 3 |
| Details | Active site in Chain A |
| Chain | Residue |
| A | SER114 |
| A | ASP169 |
| A | HIS203 |
| site_id | ACB |
| Number of Residues | 3 |
| Details | Active site in Chain B |
| Chain | Residue |
| B | SER114 |
| B | ASP169 |
| B | HIS203 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 812 |
| Chain | Residue |
| A | ASN192 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 813 |
| Chain | Residue |
| A | CYS206 |
| A | GLN208 |
| A | HOH962 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 814 |
| Chain | Residue |
| B | PRO4 |
| B | LEU5 |
| B | THR197 |
| B | HOH1029 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 815 |
| Chain | Residue |
| B | HOH847 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 816 |
| Chain | Residue |
| A | MET-5 |
| A | HOH1030 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 817 |
| Chain | Residue |
| A | HOH926 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 818 |
| Chain | Residue |
| A | PHE195 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 819 |
| Chain | Residue |
| B | HOH858 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 820 |
| Chain | Residue |
| A | HOH977 |
| A | HOH990 |
| A | HOH1024 |
| B | CYS168 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 821 |
| Chain | Residue |
| B | GLU199 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 822 |
| Chain | Residue |
| B | HIS23 |
| B | HOH1036 |
| B | HOH1079 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 823 |
| Chain | Residue |
| A | LEU5 |
| A | THR197 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 824 |
| Chain | Residue |
| A | HIS23 |
| A | HIS50 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 825 |
| Chain | Residue |
| A | ASP167 |
| A | GLY200 |
| B | ASN61 |
| B | GLN207 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 826 |
| Chain | Residue |
| B | THR197 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 827 |
| Chain | Residue |
| A | SER160 |
| A | HOH898 |
| A | HOH943 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 828 |
| Chain | Residue |
| A | PRO75 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 829 |
| Chain | Residue |
| A | ALA15 |
| A | HOH1011 |
| A | HOH1053 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR A 830 |
| Chain | Residue |
| A | GLN86 |
| A | HOH963 |
| A | HOH1032 |
| A | HOH1059 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR A 831 |
| Chain | Residue |
| A | CYS168 |
| A | MET202 |
| A | BR832 |
| B | HOH1048 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR A 832 |
| Chain | Residue |
| A | CYS168 |
| A | BR831 |
| B | HOH1044 |
| B | HOH1048 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 833 |
| Chain | Residue |
| B | LYS183 |
| B | HOH1020 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 834 |
| Chain | Residue |
| B | LYS185 |
| B | HOH1009 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 835 |
| Chain | Residue |
| B | SER41 |
| B | HIS43 |
| B | HOH889 |
| B | HOH978 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 836 |
| Chain | Residue |
| B | ASN106 |
| B | HOH903 |
| B | HOH1023 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 837 |
| Chain | Residue |
| B | GLN149 |
| B | HOH917 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 838 |
| Chain | Residue |
| B | LYS92 |
| B | GLN128 |
| B | HOH1061 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 839 |
| Chain | Residue |
| B | LYS100 |
| B | HOH851 |
| B | HOH1077 |
| site_id | EC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 840 |
| Chain | Residue |
| A | SER205 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system => ECO:0000269|PubMed:19439193, ECO:0000269|PubMed:37802024 |
| Chain | Residue | Details |
| A | SER114 | |
| B | SER114 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Charge relay system => ECO:0000305|PubMed:11080636 |
| Chain | Residue | Details |
| A | ASP169 | |
| A | HIS203 | |
| B | ASP169 | |
| B | HIS203 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P97823 |
| Chain | Residue | Details |
| A | LYS219 | |
| B | LYS219 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auo |
| Chain | Residue | Details |
| A | SER114 | |
| A | LEU25 | |
| A | ASP169 | |
| A | GLN115 | |
| A | HIS203 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auo |
| Chain | Residue | Details |
| B | SER114 | |
| B | LEU25 | |
| B | ASP169 | |
| B | GLN115 | |
| B | HIS203 |
