1FFT
The structure of ubiquinol oxidase from Escherichia coli
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005507 | molecular_function | copper ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0009055 | molecular_function | electron transfer activity |
A | 0009060 | biological_process | aerobic respiration |
A | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
A | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
A | 0015078 | molecular_function | proton transmembrane transporter activity |
A | 0015453 | molecular_function | oxidoreduction-driven active transmembrane transporter activity |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
A | 0019646 | biological_process | aerobic electron transport chain |
A | 0020037 | molecular_function | heme binding |
A | 0022904 | biological_process | respiratory electron transport chain |
A | 0046872 | molecular_function | metal ion binding |
A | 0048039 | molecular_function | ubiquinone binding |
A | 0070469 | cellular_component | respirasome |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
B | 0016020 | cellular_component | membrane |
B | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
B | 0022900 | biological_process | electron transport chain |
C | 0004129 | molecular_function | cytochrome-c oxidase activity |
C | 0009055 | molecular_function | electron transfer activity |
C | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
C | 0016020 | cellular_component | membrane |
C | 0019646 | biological_process | aerobic electron transport chain |
C | 0022904 | biological_process | respiratory electron transport chain |
F | 0004129 | molecular_function | cytochrome-c oxidase activity |
F | 0005507 | molecular_function | copper ion binding |
F | 0005515 | molecular_function | protein binding |
F | 0005886 | cellular_component | plasma membrane |
F | 0009055 | molecular_function | electron transfer activity |
F | 0009060 | biological_process | aerobic respiration |
F | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
F | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
F | 0015078 | molecular_function | proton transmembrane transporter activity |
F | 0015453 | molecular_function | oxidoreduction-driven active transmembrane transporter activity |
F | 0015990 | biological_process | electron transport coupled proton transport |
F | 0016020 | cellular_component | membrane |
F | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
F | 0019646 | biological_process | aerobic electron transport chain |
F | 0020037 | molecular_function | heme binding |
F | 0022904 | biological_process | respiratory electron transport chain |
F | 0046872 | molecular_function | metal ion binding |
F | 0048039 | molecular_function | ubiquinone binding |
F | 0070469 | cellular_component | respirasome |
F | 1902600 | biological_process | proton transmembrane transport |
G | 0004129 | molecular_function | cytochrome-c oxidase activity |
G | 0005507 | molecular_function | copper ion binding |
G | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
G | 0016020 | cellular_component | membrane |
G | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
G | 0022900 | biological_process | electron transport chain |
H | 0004129 | molecular_function | cytochrome-c oxidase activity |
H | 0009055 | molecular_function | electron transfer activity |
H | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
H | 0016020 | cellular_component | membrane |
H | 0019646 | biological_process | aerobic electron transport chain |
H | 0022904 | biological_process | respiratory electron transport chain |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CU A 1003 |
Chain | Residue |
A | HIS284 |
A | HIS333 |
A | HIS334 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CU F 1003 |
Chain | Residue |
F | HIS284 |
F | HIS333 |
F | HIS334 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEM A 1001 |
Chain | Residue |
A | PHE103 |
A | THR104 |
A | HIS106 |
A | GLY107 |
A | MET110 |
A | ILE111 |
A | GLY169 |
A | TRP170 |
A | ILE417 |
A | HIS421 |
A | ILE424 |
A | ILE425 |
A | VAL429 |
A | PHE468 |
A | ARG481 |
A | ARG482 |
A | PHE73 |
A | ARG80 |
A | TYR99 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEO A 1002 |
Chain | Residue |
A | TRP280 |
A | VAL287 |
A | HIS333 |
A | HIS334 |
A | ALA356 |
A | THR359 |
A | GLY360 |
A | GLY395 |
A | GLY398 |
A | VAL399 |
A | LEU401 |
A | HIS411 |
A | ASN412 |
A | LEU416 |
A | HIS419 |
A | PHE420 |
A | VAL423 |
A | ILE424 |
A | ARG481 |
B | ILE56 |
B | PRO96 |
B | ILE99 |
B | ILE100 |
site_id | AC5 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEM F 1001 |
Chain | Residue |
F | PHE73 |
F | ARG80 |
F | TYR99 |
F | PHE103 |
F | THR104 |
F | HIS106 |
F | GLY107 |
F | MET110 |
F | ILE111 |
F | GLY169 |
F | TRP170 |
F | ILE417 |
F | HIS421 |
F | ILE424 |
F | ILE425 |
F | VAL429 |
F | PHE468 |
F | ARG481 |
F | ARG482 |
site_id | AC6 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEO F 1002 |
Chain | Residue |
F | TRP170 |
F | TRP280 |
F | VAL287 |
F | HIS333 |
F | HIS334 |
F | ALA356 |
F | THR359 |
F | GLY360 |
F | GLY395 |
F | GLY398 |
F | VAL399 |
F | LEU401 |
F | HIS411 |
F | ASN412 |
F | LEU416 |
F | HIS419 |
F | PHE420 |
F | VAL423 |
F | ILE424 |
F | ARG481 |
G | ILE56 |
G | PRO96 |
G | ILE99 |
G | ILE100 |
Functional Information from PROSITE/UniProt
site_id | PS00077 |
Number of Residues | 55 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WAWGHPeVyililpvfgvfseiaatfsrkrlfgytslvwatvcitvlsfivwl..HH |
Chain | Residue | Details |
A | TRP280-HIS334 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 180 |
Details | TRANSMEM: Helical => ECO:0000305 |
Chain | Residue | Details |
C | TYR32-LEU50 | |
H | HIS185-ALA203 | |
F | VAL162-GLY184 | |
F | THR261-GLY270 | |
F | SER327-ALA340 | |
F | LEU410-ASN412 | |
F | GLY478-PRO489 | |
F | ILE607-LEU613 | |
C | PRO67-MET85 | |
C | LEU102-PHE120 | |
C | VAL143-MET161 | |
C | HIS185-ALA203 | |
H | TYR32-LEU50 | |
H | PRO67-MET85 | |
H | LEU102-PHE120 | |
H | VAL143-MET161 |
site_id | SWS_FT_FI2 |
Number of Residues | 74 |
Details | TOPO_DOM: Periplasmic => ECO:0000305 |
Chain | Residue | Details |
C | VAL51-LEU66 | |
C | HIS121-LEU142 | |
C | MET204 | |
H | VAL51-LEU66 | |
H | HIS121-LEU142 | |
H | MET204 |
site_id | SWS_FT_FI3 |
Number of Residues | 74 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
C | ALA86-TRP101 | |
F | ALA133-ALA137 | |
F | ARG216-LYS224 | |
F | LYS308-PHE311 | |
F | MET370-PHE377 | |
F | PHE446-LEU448 | |
F | ASP522-LYS587 | |
F | ASP633-ASN663 | |
C | VAL162-TRP184 | |
H | ALA86-TRP101 | |
H | VAL162-TRP184 | |
A | MET370-PHE377 | |
A | PHE446-LEU448 | |
A | ASP522-LYS587 | |
A | ASP633-ASN663 | |
F | THR36-VAL52 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | LIPID: S-diacylglycerol cysteine => ECO:0000255|PROSITE-ProRule:PRU00303 |
Chain | Residue | Details |
B | CYS25 | |
G | CYS25 |
site_id | SWS_FT_FI5 |
Number of Residues | 72 |
Details | TRANSMEM: Helical; Name=III |
Chain | Residue | Details |
A | PRO96-GLY132 | |
F | PRO96-GLY132 |
site_id | SWS_FT_FI6 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=IV |
Chain | Residue | Details |
A | PHE138-GLY161 | |
F | PHE138-GLY161 |
site_id | SWS_FT_FI7 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=V |
Chain | Residue | Details |
A | VAL185-MET215 | |
F | VAL185-MET215 |
site_id | SWS_FT_FI8 |
Number of Residues | 70 |
Details | TRANSMEM: Helical; Name=VI |
Chain | Residue | Details |
A | MET225-GLY260 | |
F | MET225-GLY260 |
site_id | SWS_FT_FI9 |
Number of Residues | 72 |
Details | TRANSMEM: Helical; Name=VII |
Chain | Residue | Details |
A | ASN271-ARG307 | |
F | ASN271-ARG307 |
site_id | SWS_FT_FI10 |
Number of Residues | 28 |
Details | TRANSMEM: Helical; Name=VIII |
Chain | Residue | Details |
A | GLY312-LEU326 | |
F | GLY312-LEU326 |
site_id | SWS_FT_FI11 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=IX |
Chain | Residue | Details |
A | GLY341-THR369 | |
F | GLY341-THR369 |
site_id | SWS_FT_FI12 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=X |
Chain | Residue | Details |
A | HIS378-VAL409 | |
F | HIS378-VAL409 |
site_id | SWS_FT_FI13 |
Number of Residues | 64 |
Details | TRANSMEM: Helical; Name=XI |
Chain | Residue | Details |
A | SER413-GLY445 | |
F | SER413-GLY445 |
site_id | SWS_FT_FI14 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=XII |
Chain | Residue | Details |
A | ASN449-MET477 | |
F | ASN449-MET477 |
site_id | SWS_FT_FI15 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=XIII |
Chain | Residue | Details |
A | GLN490-ARG521 | |
F | GLN490-ARG521 |
site_id | SWS_FT_FI16 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=XIV |
Chain | Residue | Details |
A | ASN588-MET606 | |
F | ASN588-MET606 |
site_id | SWS_FT_FI17 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=XV |
Chain | Residue | Details |
A | ALA614-GLU632 | |
F | ALA614-GLU632 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33408407, ECO:0000269|PubMed:34417297, ECO:0007744|PDB:6WTI, ECO:0007744|PDB:7CUB, ECO:0007744|PDB:7CUW, ECO:0007744|PDB:7N9Z |
Chain | Residue | Details |
A | ARG71 | |
F | ARG71 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34417297, ECO:0007744|PDB:7CUW |
Chain | Residue | Details |
A | ASP75 | |
F | ASP75 |
site_id | SWS_FT_FI20 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34417297, ECO:0007744|PDB:7CUB, ECO:0007744|PDB:7CUW, ECO:0007744|PDB:7N9Z |
Chain | Residue | Details |
A | HIS98 | |
F | HIS98 |
site_id | SWS_FT_FI21 |
Number of Residues | 6 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:11017202, ECO:0000269|PubMed:33408407, ECO:0007744|PDB:1FFT, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | HIS106 | |
A | HIS419 | |
A | HIS421 | |
F | HIS106 | |
F | HIS419 | |
F | HIS421 |
site_id | SWS_FT_FI22 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11017202, ECO:0007744|PDB:1FFT |
Chain | Residue | Details |
A | TRP170 | |
F | TRP170 |
site_id | SWS_FT_FI23 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11017202, ECO:0000269|PubMed:33408407, ECO:0007744|PDB:1FFT, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | HIS284 | |
F | ARG482 | |
A | HIS333 | |
A | HIS334 | |
A | HIS411 | |
A | ARG482 | |
F | HIS284 | |
F | HIS333 | |
F | HIS334 | |
F | HIS411 |
site_id | SWS_FT_FI24 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33408407, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | TYR288 | |
A | ARG481 | |
F | TYR288 | |
F | ARG481 |
site_id | SWS_FT_FI25 |
Number of Residues | 4 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:34417297 |
Chain | Residue | Details |
A | HIS284 | |
A | TYR288 | |
F | HIS284 | |
F | TYR288 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 23 |
Details | a catalytic site defined by CSA, PubMed 11017202, 15598510, 12450405, 16624801, 9256439 |
Chain | Residue | Details |
A | HIS419 | |
A | THR201 | |
A | SER145 | |
A | MET79 | |
A | ASN124 | |
A | PHE420 | |
A | PHE103 | |
A | GLU286 | |
A | THR149 | |
A | HIS284 | |
A | HIS421 | |
A | LYS362 | |
A | THR204 | |
A | ASP75 | |
A | ARG71 | |
A | TYR288 | |
A | ASP135 | |
A | THR211 | |
A | THR359 | |
A | SER315 | |
A | SER299 | |
A | ASN142 | |
A | TYR61 |
site_id | CSA2 |
Number of Residues | 23 |
Details | a catalytic site defined by CSA, PubMed 11017202, 15598510, 12450405, 16624801, 9256439 |
Chain | Residue | Details |
F | HIS419 | |
F | THR201 | |
F | SER145 | |
F | MET79 | |
F | ASN124 | |
F | PHE420 | |
F | PHE103 | |
F | GLU286 | |
F | THR149 | |
F | HIS284 | |
F | HIS421 | |
F | LYS362 | |
F | THR204 | |
F | ASP75 | |
F | ARG71 | |
F | TYR288 | |
F | ASP135 | |
F | THR211 | |
F | THR359 | |
F | SER315 | |
F | SER299 | |
F | ASN142 | |
F | TYR61 |
site_id | MCSA1 |
Number of Residues | 23 |
Details | M-CSA 714 |
Chain | Residue | Details |
A | TYR61 | proton shuttle (general acid/base) |
A | THR149 | proton shuttle (general acid/base) |
A | THR201 | proton shuttle (general acid/base) |
A | THR204 | proton shuttle (general acid/base) |
A | THR211 | proton shuttle (general acid/base) |
A | HIS284 | metal ligand, modifies pKa |
A | GLU286 | proton shuttle (general acid/base) |
A | TYR288 | electron shuttle, proton shuttle (general acid/base) |
A | SER299 | proton shuttle (general acid/base) |
A | SER315 | proton shuttle (general acid/base) |
A | THR359 | proton shuttle (general acid/base) |
A | ARG71 | electrostatic stabiliser |
A | LYS362 | proton shuttle (general acid/base) |
A | HIS419 | electron shuttle |
A | PHE420 | electron shuttle |
A | HIS421 | electron shuttle |
A | ASP75 | electrostatic stabiliser |
A | MET79 | electron shuttle |
A | PHE103 | electron shuttle |
A | ASN124 | proton shuttle (general acid/base) |
A | ASP135 | proton shuttle (general acid/base) |
A | ASN142 | proton shuttle (general acid/base) |
A | SER145 | proton shuttle (general acid/base) |
site_id | MCSA2 |
Number of Residues | 23 |
Details | M-CSA 714 |
Chain | Residue | Details |
F | TYR61 | proton shuttle (general acid/base) |
F | THR149 | proton shuttle (general acid/base) |
F | THR201 | proton shuttle (general acid/base) |
F | THR204 | proton shuttle (general acid/base) |
F | THR211 | proton shuttle (general acid/base) |
F | HIS284 | metal ligand, modifies pKa |
F | GLU286 | proton shuttle (general acid/base) |
F | TYR288 | electron shuttle, proton shuttle (general acid/base) |
F | SER299 | proton shuttle (general acid/base) |
F | SER315 | proton shuttle (general acid/base) |
F | THR359 | proton shuttle (general acid/base) |
F | ARG71 | electrostatic stabiliser |
F | LYS362 | proton shuttle (general acid/base) |
F | HIS419 | electron shuttle |
F | PHE420 | electron shuttle |
F | HIS421 | electron shuttle |
F | ASP75 | electrostatic stabiliser |
F | MET79 | electron shuttle |
F | PHE103 | electron shuttle |
F | ASN124 | proton shuttle (general acid/base) |
F | ASP135 | proton shuttle (general acid/base) |
F | ASN142 | proton shuttle (general acid/base) |
F | SER145 | proton shuttle (general acid/base) |