1FDT

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRADIOL AND NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0005496	molecular_function	steroid binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006703	biological_process	estrogen biosynthetic process
A	0007040	biological_process	lysosome organization
A	0007519	biological_process	skeletal muscle tissue development
A	0008210	biological_process	estrogen metabolic process
A	0010467	biological_process	gene expression
A	0016491	molecular_function	oxidoreductase activity
A	0030283	molecular_function	testosterone dehydrogenase [NAD(P)+] activity
A	0036094	molecular_function	small molecule binding
A	0042803	molecular_function	protein homodimerization activity
A	0047035	molecular_function	testosterone dehydrogenase (NAD+) activity
A	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
A	0050661	molecular_function	NADP binding
A	0060348	biological_process	bone development
A	0060612	biological_process	adipose tissue development
A	0061370	biological_process	testosterone biosynthetic process
A	0070401	molecular_function	NADP+ binding
A	0071248	biological_process	cellular response to metal ion
A	0072582	molecular_function	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	1903924	molecular_function	estradiol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 380

Chain	Residue
A	GLY145
A	LEU146
A	PHE160
A	PHE160
A	GLU163
A	ARG266
A	ARG266
A	HOH425

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EST A 350

Chain	Residue
A	VAL143
A	LEU149
A	TYR155
A	HIS221
A	PHE226
A	PHE259
A	MET279
A	GLU282
A	NAP360
A	SER142

---

site_id	AC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAP A 360

Chain	Residue
A	GLY9
A	CYS10
A	SER11
A	SER12
A	GLY13
A	ILE14
A	GLY15
A	THR35
A	LEU36
A	ARG37
A	LEU64
A	ASP65
A	VAL66
A	ARG67
A	ASN90
A	ALA91
A	GLY92
A	THR140
A	GLY141
A	TYR155
A	LYS159
A	CYS185
A	GLY186
A	VAL188
A	THR190
A	PHE192
A	EST350
A	HOH405
A	HOH408
A	HOH427
A	HOH441

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA

Chain	Residue	Details
A	SER142-ALA170

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	CYS156

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:8805577

Chain	Residue	Details
A	CYS10
A	VAL66
A	VAL143
A	PHE160

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8994190

Chain	Residue	Details
A	GLY135

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
A	ASN152
A	LYS159

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
A	TYR155
A	LYS159

---