Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1FDH

STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0016020	cellular_component	membrane
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0031720	molecular_function	haptoglobin binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005833	cellular_component	hemoglobin complex
G	0015670	biological_process	carbon dioxide transport
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0031720	molecular_function	haptoglobin binding
G	0031721	molecular_function	hemoglobin alpha binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005833	cellular_component	hemoglobin complex
H	0015670	biological_process	carbon dioxide transport
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0072562	cellular_component	blood microparticle
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM A 142

Chain	Residue
A	TYR42
A	LEU91
A	VAL93
A	ASN97
A	PHE98
A	LEU101
A	LEU136
A	PHE43
A	HIS45
A	PHE46
A	HIS58
A	LYS61
A	LEU83
A	LEU86
A	HIS87

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM G 147

Chain	Residue
G	HIS63
G	VAL67
G	SER70
G	PHE85
G	LEU88
G	LEU91
G	HIS92
G	LEU96
G	ASN102
G	LEU106
G	LEU141
H	GLU5

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM B 142

Chain	Residue
B	TYR42
B	PHE43
B	HIS45
B	PHE46
B	HIS58
B	LYS61
B	LEU83
B	LEU86
B	HIS87
B	LEU91
B	VAL93
B	ASN97
B	PHE98
B	LEU101
B	LEU136

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM H 147

Chain	Residue
B	HIS72
H	HIS63
H	VAL67
H	SER70
H	PHE85
H	LEU88
H	LEU91
H	HIS92
H	LEU96
H	ASN102
H	LEU106
H	LEU141

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: distal binding residue => ECO:0000250\|UniProtKB:P80044

Chain	Residue	Details
H	HIS63
G	HIS63
G	PRO58
H	PRO58

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000269\|PubMed:11514664, ECO:0007744\|PDB:1I3D, ECO:0007744\|PDB:1I3E

Chain	Residue	Details
G	GLN87
H	GLN87

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
G	ASP7
H	ASP7
G	THR12
H	THR12
A	PHE46
A	LEU48
A	ALA53
A	LYS56
A	LYS60
A	ARG92
A	VAL107
A	LEU109
A	HIS122
A	THR134
B	ASN9
B	TRP14
B	GLY25
B	GLU30
B	PHE46
B	LEU48
B	ALA53
B	LYS56
B	LYS60
B	ARG92
B	VAL107
B	LEU109
B	HIS122
B	THR134

site_id	SWS_FT_FI4
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
H	SER52
H	SER139
H	SER142
H	SER143
G	SER52
G	SER139
G	SER142
G	SER143
H	SER44
H	SER50
G	GLN39
G	PHE45
G	ASN47
G	VAL134
H	GLN39
H	PHE45
H	ASN47
H	VAL134
G	SER44
G	SER50

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
G	ILE54
G	HIS77
H	ILE54
H	HIS77
G	LYS59
G	LYS82
H	LYS59
H	LYS82

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
G	LEU88
H	LEU88
G	CYS93
H	CYS93
B	VAL17
B	THR41

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000269\|PubMed:881729, ECO:0007744\|PDB:1FDH, ECO:0007744\|PDB:4MQJ, ECO:0007744\|PDB:4MQK

Chain	Residue	Details
G	HIS92
H	HIS92

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N-acetylglycine; in form Hb F1 => ECO:0000269\|PubMed:5554303

Chain	Residue	Details
G	GLY1
H	GLY1

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	GLY25
B	GLY25

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	HIS103
A	LEU125
A	VAL132
A	LYS139
B	HIS103
B	LEU125
B	VAL132
B	LYS139

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	LEU109
A	VAL135
A	SER138
B	LEU109
B	VAL135
B	SER138

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
A	THR8
A	VAL17
A	THR41
B	THR8
B	VAL17
B	THR41

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
A	VAL62
B	VAL62

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)