1FDH
STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004601 | molecular_function | peroxidase activity |
A | 0005344 | molecular_function | oxygen carrier activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005829 | cellular_component | cytosol |
A | 0005833 | cellular_component | hemoglobin complex |
A | 0015670 | biological_process | carbon dioxide transport |
A | 0015671 | biological_process | oxygen transport |
A | 0016020 | cellular_component | membrane |
A | 0019825 | molecular_function | oxygen binding |
A | 0020037 | molecular_function | heme binding |
A | 0030185 | biological_process | nitric oxide transport |
A | 0031720 | molecular_function | haptoglobin binding |
A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
A | 0042542 | biological_process | response to hydrogen peroxide |
A | 0042744 | biological_process | hydrogen peroxide catabolic process |
A | 0043177 | molecular_function | organic acid binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071682 | cellular_component | endocytic vesicle lumen |
A | 0072562 | cellular_component | blood microparticle |
A | 0098869 | biological_process | cellular oxidant detoxification |
B | 0004601 | molecular_function | peroxidase activity |
B | 0005344 | molecular_function | oxygen carrier activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005829 | cellular_component | cytosol |
B | 0005833 | cellular_component | hemoglobin complex |
B | 0015670 | biological_process | carbon dioxide transport |
B | 0015671 | biological_process | oxygen transport |
B | 0016020 | cellular_component | membrane |
B | 0019825 | molecular_function | oxygen binding |
B | 0020037 | molecular_function | heme binding |
B | 0030185 | biological_process | nitric oxide transport |
B | 0031720 | molecular_function | haptoglobin binding |
B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
B | 0042542 | biological_process | response to hydrogen peroxide |
B | 0042744 | biological_process | hydrogen peroxide catabolic process |
B | 0043177 | molecular_function | organic acid binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071682 | cellular_component | endocytic vesicle lumen |
B | 0072562 | cellular_component | blood microparticle |
B | 0098869 | biological_process | cellular oxidant detoxification |
G | 0004601 | molecular_function | peroxidase activity |
G | 0005344 | molecular_function | oxygen carrier activity |
G | 0005515 | molecular_function | protein binding |
G | 0005829 | cellular_component | cytosol |
G | 0005833 | cellular_component | hemoglobin complex |
G | 0015670 | biological_process | carbon dioxide transport |
G | 0015671 | biological_process | oxygen transport |
G | 0019825 | molecular_function | oxygen binding |
G | 0020037 | molecular_function | heme binding |
G | 0031720 | molecular_function | haptoglobin binding |
G | 0031721 | molecular_function | hemoglobin alpha binding |
G | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
G | 0042744 | biological_process | hydrogen peroxide catabolic process |
G | 0043177 | molecular_function | organic acid binding |
G | 0046872 | molecular_function | metal ion binding |
G | 0072562 | cellular_component | blood microparticle |
G | 0098869 | biological_process | cellular oxidant detoxification |
H | 0004601 | molecular_function | peroxidase activity |
H | 0005344 | molecular_function | oxygen carrier activity |
H | 0005515 | molecular_function | protein binding |
H | 0005829 | cellular_component | cytosol |
H | 0005833 | cellular_component | hemoglobin complex |
H | 0015670 | biological_process | carbon dioxide transport |
H | 0015671 | biological_process | oxygen transport |
H | 0019825 | molecular_function | oxygen binding |
H | 0020037 | molecular_function | heme binding |
H | 0031720 | molecular_function | haptoglobin binding |
H | 0031721 | molecular_function | hemoglobin alpha binding |
H | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
H | 0042744 | biological_process | hydrogen peroxide catabolic process |
H | 0043177 | molecular_function | organic acid binding |
H | 0046872 | molecular_function | metal ion binding |
H | 0072562 | cellular_component | blood microparticle |
H | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HEM A 142 |
Chain | Residue |
A | TYR42 |
A | LEU91 |
A | VAL93 |
A | ASN97 |
A | PHE98 |
A | LEU101 |
A | LEU136 |
A | PHE43 |
A | HIS45 |
A | PHE46 |
A | HIS58 |
A | LYS61 |
A | LEU83 |
A | LEU86 |
A | HIS87 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE HEM G 147 |
Chain | Residue |
G | HIS63 |
G | VAL67 |
G | SER70 |
G | PHE85 |
G | LEU88 |
G | LEU91 |
G | HIS92 |
G | LEU96 |
G | ASN102 |
G | LEU106 |
G | LEU141 |
H | GLU5 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HEM B 142 |
Chain | Residue |
B | TYR42 |
B | PHE43 |
B | HIS45 |
B | PHE46 |
B | HIS58 |
B | LYS61 |
B | LEU83 |
B | LEU86 |
B | HIS87 |
B | LEU91 |
B | VAL93 |
B | ASN97 |
B | PHE98 |
B | LEU101 |
B | LEU136 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE HEM H 147 |
Chain | Residue |
B | HIS72 |
H | HIS63 |
H | VAL67 |
H | SER70 |
H | PHE85 |
H | LEU88 |
H | LEU91 |
H | HIS92 |
H | LEU96 |
H | ASN102 |
H | LEU106 |
H | LEU141 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: distal binding residue => ECO:0000250|UniProtKB:P80044 |
Chain | Residue | Details |
G | PRO58 | |
H | PRO58 | |
G | HIS63 | |
H | HIS63 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: proximal binding residue => ECO:0000269|PubMed:11514664, ECO:0007744|PDB:1I3D, ECO:0007744|PDB:1I3E |
Chain | Residue | Details |
G | GLN87 | |
H | GLN87 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
G | ASP7 | |
A | ARG92 | |
A | VAL107 | |
A | LEU109 | |
A | HIS122 | |
A | THR134 | |
B | ASN9 | |
B | TRP14 | |
B | GLY25 | |
B | GLU30 | |
B | PHE46 | |
H | ASP7 | |
B | LEU48 | |
B | ALA53 | |
B | LYS56 | |
B | LYS60 | |
B | ARG92 | |
B | VAL107 | |
B | LEU109 | |
B | HIS122 | |
B | THR134 | |
G | THR12 | |
H | THR12 | |
A | PHE46 | |
A | LEU48 | |
A | ALA53 | |
A | LYS56 | |
A | LYS60 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
G | GLN39 | |
G | SER50 | |
G | SER52 | |
G | SER139 | |
G | SER142 | |
G | SER143 | |
H | SER44 | |
H | SER50 | |
H | SER52 | |
H | SER139 | |
H | SER142 | |
G | PHE45 | |
H | SER143 | |
G | ASN47 | |
G | VAL134 | |
H | GLN39 | |
H | PHE45 | |
H | ASN47 | |
H | VAL134 | |
G | SER44 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
G | ILE54 | |
G | HIS77 | |
H | ILE54 | |
H | HIS77 | |
G | LYS59 | |
G | LYS82 | |
H | LYS59 | |
H | LYS82 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
G | LEU88 | |
H | LEU88 | |
G | CYS93 | |
H | CYS93 | |
B | VAL17 | |
B | THR41 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: proximal binding residue => ECO:0000269|PubMed:881729, ECO:0007744|PDB:1FDH, ECO:0007744|PDB:4MQJ, ECO:0007744|PDB:4MQK |
Chain | Residue | Details |
G | HIS92 | |
H | HIS92 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylglycine; in form Hb F1 => ECO:0000269|PubMed:5554303 |
Chain | Residue | Details |
G | GLY1 | |
H | GLY1 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | GLY25 | |
B | GLY25 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942 |
Chain | Residue | Details |
A | HIS103 | |
A | LEU125 | |
A | VAL132 | |
A | LYS139 | |
B | HIS103 | |
B | LEU125 | |
B | VAL132 | |
B | LYS139 |
site_id | SWS_FT_FI11 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942 |
Chain | Residue | Details |
A | LEU109 | |
A | VAL135 | |
A | SER138 | |
B | LEU109 | |
B | VAL135 | |
B | SER138 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
Chain | Residue | Details |
A | THR8 | |
A | VAL17 | |
A | THR41 | |
B | THR8 | |
B | VAL17 | |
B | THR41 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
Chain | Residue | Details |
A | VAL62 | |
B | VAL62 |