1FD4

HUMAN BETA-DEFENSIN 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005796	cellular_component	Golgi lumen
A	0006935	biological_process	chemotaxis
A	0006952	biological_process	defense response
A	0006955	biological_process	immune response
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0031640	biological_process	killing of cells of another organism
A	0031731	molecular_function	CCR6 chemokine receptor binding
A	0042056	molecular_function	chemoattractant activity
A	0042742	biological_process	defense response to bacterium
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050832	biological_process	defense response to fungus
A	0050918	biological_process	positive chemotaxis
A	0060326	biological_process	cell chemotaxis
A	0061760	biological_process	antifungal innate immune response
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0140546	biological_process	defense response to symbiont
B	0005515	molecular_function	protein binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005796	cellular_component	Golgi lumen
B	0006935	biological_process	chemotaxis
B	0006952	biological_process	defense response
B	0006955	biological_process	immune response
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0031640	biological_process	killing of cells of another organism
B	0031731	molecular_function	CCR6 chemokine receptor binding
B	0042056	molecular_function	chemoattractant activity
B	0042742	biological_process	defense response to bacterium
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0050832	biological_process	defense response to fungus
B	0050918	biological_process	positive chemotaxis
B	0060326	biological_process	cell chemotaxis
B	0061760	biological_process	antifungal innate immune response
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0140546	biological_process	defense response to symbiont
C	0005515	molecular_function	protein binding
C	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005796	cellular_component	Golgi lumen
C	0006935	biological_process	chemotaxis
C	0006952	biological_process	defense response
C	0006955	biological_process	immune response
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0031640	biological_process	killing of cells of another organism
C	0031731	molecular_function	CCR6 chemokine receptor binding
C	0042056	molecular_function	chemoattractant activity
C	0042742	biological_process	defense response to bacterium
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0050832	biological_process	defense response to fungus
C	0050918	biological_process	positive chemotaxis
C	0060326	biological_process	cell chemotaxis
C	0061760	biological_process	antifungal innate immune response
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0140546	biological_process	defense response to symbiont
D	0005515	molecular_function	protein binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005796	cellular_component	Golgi lumen
D	0006935	biological_process	chemotaxis
D	0006952	biological_process	defense response
D	0006955	biological_process	immune response
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0031640	biological_process	killing of cells of another organism
D	0031731	molecular_function	CCR6 chemokine receptor binding
D	0042056	molecular_function	chemoattractant activity
D	0042742	biological_process	defense response to bacterium
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0050832	biological_process	defense response to fungus
D	0050918	biological_process	positive chemotaxis
D	0060326	biological_process	cell chemotaxis
D	0061760	biological_process	antifungal innate immune response
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0140546	biological_process	defense response to symbiont
E	0005515	molecular_function	protein binding
E	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005796	cellular_component	Golgi lumen
E	0006935	biological_process	chemotaxis
E	0006952	biological_process	defense response
E	0006955	biological_process	immune response
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0031640	biological_process	killing of cells of another organism
E	0031731	molecular_function	CCR6 chemokine receptor binding
E	0042056	molecular_function	chemoattractant activity
E	0042742	biological_process	defense response to bacterium
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0050832	biological_process	defense response to fungus
E	0050918	biological_process	positive chemotaxis
E	0060326	biological_process	cell chemotaxis
E	0061760	biological_process	antifungal innate immune response
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0140546	biological_process	defense response to symbiont
F	0005515	molecular_function	protein binding
F	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005796	cellular_component	Golgi lumen
F	0006935	biological_process	chemotaxis
F	0006952	biological_process	defense response
F	0006955	biological_process	immune response
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0031640	biological_process	killing of cells of another organism
F	0031731	molecular_function	CCR6 chemokine receptor binding
F	0042056	molecular_function	chemoattractant activity
F	0042742	biological_process	defense response to bacterium
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0050832	biological_process	defense response to fungus
F	0050918	biological_process	positive chemotaxis
F	0060326	biological_process	cell chemotaxis
F	0061760	biological_process	antifungal innate immune response
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0140546	biological_process	defense response to symbiont
G	0005515	molecular_function	protein binding
G	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005796	cellular_component	Golgi lumen
G	0006935	biological_process	chemotaxis
G	0006952	biological_process	defense response
G	0006955	biological_process	immune response
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0031640	biological_process	killing of cells of another organism
G	0031731	molecular_function	CCR6 chemokine receptor binding
G	0042056	molecular_function	chemoattractant activity
G	0042742	biological_process	defense response to bacterium
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0050832	biological_process	defense response to fungus
G	0050918	biological_process	positive chemotaxis
G	0060326	biological_process	cell chemotaxis
G	0061760	biological_process	antifungal innate immune response
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0140546	biological_process	defense response to symbiont
H	0005515	molecular_function	protein binding
H	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005796	cellular_component	Golgi lumen
H	0006935	biological_process	chemotaxis
H	0006952	biological_process	defense response
H	0006955	biological_process	immune response
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0031640	biological_process	killing of cells of another organism
H	0031731	molecular_function	CCR6 chemokine receptor binding
H	0042056	molecular_function	chemoattractant activity
H	0042742	biological_process	defense response to bacterium
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0050832	biological_process	defense response to fungus
H	0050918	biological_process	positive chemotaxis
H	0060326	biological_process	cell chemotaxis
H	0061760	biological_process	antifungal innate immune response
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0140546	biological_process	defense response to symbiont
I	0005515	molecular_function	protein binding
I	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005796	cellular_component	Golgi lumen
I	0006935	biological_process	chemotaxis
I	0006952	biological_process	defense response
I	0006955	biological_process	immune response
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0031640	biological_process	killing of cells of another organism
I	0031731	molecular_function	CCR6 chemokine receptor binding
I	0042056	molecular_function	chemoattractant activity
I	0042742	biological_process	defense response to bacterium
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0050832	biological_process	defense response to fungus
I	0050918	biological_process	positive chemotaxis
I	0060326	biological_process	cell chemotaxis
I	0061760	biological_process	antifungal innate immune response
I	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
I	0140546	biological_process	defense response to symbiont
J	0005515	molecular_function	protein binding
J	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005796	cellular_component	Golgi lumen
J	0006935	biological_process	chemotaxis
J	0006952	biological_process	defense response
J	0006955	biological_process	immune response
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0031640	biological_process	killing of cells of another organism
J	0031731	molecular_function	CCR6 chemokine receptor binding
J	0042056	molecular_function	chemoattractant activity
J	0042742	biological_process	defense response to bacterium
J	0050829	biological_process	defense response to Gram-negative bacterium
J	0050830	biological_process	defense response to Gram-positive bacterium
J	0050832	biological_process	defense response to fungus
J	0050918	biological_process	positive chemotaxis
J	0060326	biological_process	cell chemotaxis
J	0061760	biological_process	antifungal innate immune response
J	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
J	0140546	biological_process	defense response to symbiont
K	0005515	molecular_function	protein binding
K	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005796	cellular_component	Golgi lumen
K	0006935	biological_process	chemotaxis
K	0006952	biological_process	defense response
K	0006955	biological_process	immune response
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0031640	biological_process	killing of cells of another organism
K	0031731	molecular_function	CCR6 chemokine receptor binding
K	0042056	molecular_function	chemoattractant activity
K	0042742	biological_process	defense response to bacterium
K	0050829	biological_process	defense response to Gram-negative bacterium
K	0050830	biological_process	defense response to Gram-positive bacterium
K	0050832	biological_process	defense response to fungus
K	0050918	biological_process	positive chemotaxis
K	0060326	biological_process	cell chemotaxis
K	0061760	biological_process	antifungal innate immune response
K	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0140546	biological_process	defense response to symbiont
L	0005515	molecular_function	protein binding
L	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005796	cellular_component	Golgi lumen
L	0006935	biological_process	chemotaxis
L	0006952	biological_process	defense response
L	0006955	biological_process	immune response
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0031640	biological_process	killing of cells of another organism
L	0031731	molecular_function	CCR6 chemokine receptor binding
L	0042056	molecular_function	chemoattractant activity
L	0042742	biological_process	defense response to bacterium
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0050832	biological_process	defense response to fungus
L	0050918	biological_process	positive chemotaxis
L	0060326	biological_process	cell chemotaxis
L	0061760	biological_process	antifungal innate immune response
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0140546	biological_process	defense response to symbiont
M	0005515	molecular_function	protein binding
M	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005796	cellular_component	Golgi lumen
M	0006935	biological_process	chemotaxis
M	0006952	biological_process	defense response
M	0006955	biological_process	immune response
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0031640	biological_process	killing of cells of another organism
M	0031731	molecular_function	CCR6 chemokine receptor binding
M	0042056	molecular_function	chemoattractant activity
M	0042742	biological_process	defense response to bacterium
M	0050829	biological_process	defense response to Gram-negative bacterium
M	0050830	biological_process	defense response to Gram-positive bacterium
M	0050832	biological_process	defense response to fungus
M	0050918	biological_process	positive chemotaxis
M	0060326	biological_process	cell chemotaxis
M	0061760	biological_process	antifungal innate immune response
M	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
M	0140546	biological_process	defense response to symbiont
N	0005515	molecular_function	protein binding
N	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005796	cellular_component	Golgi lumen
N	0006935	biological_process	chemotaxis
N	0006952	biological_process	defense response
N	0006955	biological_process	immune response
N	0007186	biological_process	G protein-coupled receptor signaling pathway
N	0031640	biological_process	killing of cells of another organism
N	0031731	molecular_function	CCR6 chemokine receptor binding
N	0042056	molecular_function	chemoattractant activity
N	0042742	biological_process	defense response to bacterium
N	0050829	biological_process	defense response to Gram-negative bacterium
N	0050830	biological_process	defense response to Gram-positive bacterium
N	0050832	biological_process	defense response to fungus
N	0050918	biological_process	positive chemotaxis
N	0060326	biological_process	cell chemotaxis
N	0061760	biological_process	antifungal innate immune response
N	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
N	0140546	biological_process	defense response to symbiont
O	0005515	molecular_function	protein binding
O	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005796	cellular_component	Golgi lumen
O	0006935	biological_process	chemotaxis
O	0006952	biological_process	defense response
O	0006955	biological_process	immune response
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0031640	biological_process	killing of cells of another organism
O	0031731	molecular_function	CCR6 chemokine receptor binding
O	0042056	molecular_function	chemoattractant activity
O	0042742	biological_process	defense response to bacterium
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0050830	biological_process	defense response to Gram-positive bacterium
O	0050832	biological_process	defense response to fungus
O	0050918	biological_process	positive chemotaxis
O	0060326	biological_process	cell chemotaxis
O	0061760	biological_process	antifungal innate immune response
O	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
O	0140546	biological_process	defense response to symbiont
P	0005515	molecular_function	protein binding
P	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005796	cellular_component	Golgi lumen
P	0006935	biological_process	chemotaxis
P	0006952	biological_process	defense response
P	0006955	biological_process	immune response
P	0007186	biological_process	G protein-coupled receptor signaling pathway
P	0031640	biological_process	killing of cells of another organism
P	0031731	molecular_function	CCR6 chemokine receptor binding
P	0042056	molecular_function	chemoattractant activity
P	0042742	biological_process	defense response to bacterium
P	0050829	biological_process	defense response to Gram-negative bacterium
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0050832	biological_process	defense response to fungus
P	0050918	biological_process	positive chemotaxis
P	0060326	biological_process	cell chemotaxis
P	0061760	biological_process	antifungal innate immune response
P	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
P	0140546	biological_process	defense response to symbiont

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 M 807

Chain	Residue
I	ARG22
I	SO4810
I	HOH846
I	HOH859
M	TYR24
M	LYS40
M	HOH844
N	HOH88

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 808

Chain	Residue
F	ARG23
F	TYR24
F	LYS40
F	HOH828
F	HOH843
F	HOH854
E	ARG23

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 I 809

Chain	Residue
I	ARG22
I	HOH821
I	HOH829
I	HOH831
I	HOH859
N	PRO21
N	ARG22
N	ARG23

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 I 810

Chain	Residue
I	ARG22
I	HOH830
I	HOH864
M	LYS40
M	SO4807
M	HOH829
M	HOH833

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 811

Chain	Residue
A	CYS20
A	LYS25
A	GLN26

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	640
Details	Peptide: {"description":"Defensin beta 4A","featureId":"PRO_0000006968"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	Region: {"description":"Phosphatidylinositol 4,5-bisphosphate (PIP2) binding","evidences":[{"source":"PubMed","id":"30050988","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---