1FCJ
CRYSTAL STRUCTURE OF OASS COMPLEXED WITH CHLORIDE AND SULFATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004122 | molecular_function | cystathionine beta-synthase activity |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0008152 | biological_process | metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004122 | molecular_function | cystathionine beta-synthase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0008152 | biological_process | metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004122 | molecular_function | cystathionine beta-synthase activity |
| C | 0004124 | molecular_function | cysteine synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006535 | biological_process | cysteine biosynthetic process from serine |
| C | 0008152 | biological_process | metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0019344 | biological_process | cysteine biosynthetic process |
| C | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004122 | molecular_function | cystathionine beta-synthase activity |
| D | 0004124 | molecular_function | cysteine synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006535 | biological_process | cysteine biosynthetic process from serine |
| D | 0008152 | biological_process | metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0019344 | biological_process | cysteine biosynthetic process |
| D | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2001 |
| Chain | Residue |
| A | THR68 |
| A | ASN69 |
| A | GLY70 |
| A | THR72 |
| A | GLN142 |
| A | HOH3178 |
| A | HOH3276 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2002 |
| Chain | Residue |
| C | GLY70 |
| C | ASN71 |
| C | THR72 |
| C | GLY73 |
| C | GLN142 |
| C | HOH3149 |
| C | THR68 |
| C | ASN69 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2003 |
| Chain | Residue |
| B | THR68 |
| B | ASN69 |
| B | GLY70 |
| B | ASN71 |
| B | THR72 |
| B | GLY73 |
| B | GLN142 |
| B | HOH3051 |
| B | HOH3109 |
| B | HOH3128 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2004 |
| Chain | Residue |
| D | THR68 |
| D | ASN69 |
| D | GLY70 |
| D | ASN71 |
| D | THR72 |
| D | GLY73 |
| D | GLN142 |
| D | HOH3250 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 2005 |
| Chain | Residue |
| A | ASN7 |
| C | ARG34 |
| C | LEU268 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 2006 |
| Chain | Residue |
| A | ARG34 |
| A | LEU268 |
| C | ASN7 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 2007 |
| Chain | Residue |
| B | ASN7 |
| D | LEU268 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 2008 |
| Chain | Residue |
| B | LEU268 |
| D | ASN7 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP A 3001 |
| Chain | Residue |
| A | LYS41 |
| A | ASN71 |
| A | GLY174 |
| A | VAL175 |
| A | GLY176 |
| A | THR177 |
| A | GLY178 |
| A | THR180 |
| A | GLY228 |
| A | ILE229 |
| A | SER272 |
| A | PRO299 |
| A | SER300 |
| A | HOH3010 |
| A | HOH3016 |
| A | HOH3090 |
| A | HOH3276 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP C 3002 |
| Chain | Residue |
| C | LYS41 |
| C | ASN71 |
| C | GLY174 |
| C | GLY176 |
| C | THR177 |
| C | GLY178 |
| C | GLY179 |
| C | THR180 |
| C | GLY228 |
| C | ILE229 |
| C | SER272 |
| C | PRO299 |
| C | SER300 |
| C | HOH3008 |
| C | HOH3012 |
| C | HOH3030 |
| C | HOH3072 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP B 3003 |
| Chain | Residue |
| B | LYS41 |
| B | ASN71 |
| B | GLY174 |
| B | VAL175 |
| B | GLY176 |
| B | THR177 |
| B | GLY178 |
| B | GLY179 |
| B | THR180 |
| B | GLY228 |
| B | ILE229 |
| B | SER272 |
| B | PRO299 |
| B | SER300 |
| B | HOH3007 |
| B | HOH3014 |
| B | HOH3044 |
| B | HOH3051 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP D 3004 |
| Chain | Residue |
| D | GLY176 |
| D | THR177 |
| D | GLY178 |
| D | THR180 |
| D | GLY228 |
| D | ILE229 |
| D | SER272 |
| D | PRO299 |
| D | HOH3005 |
| D | HOH3018 |
| D | HOH3039 |
| D | LYS41 |
| D | ASN71 |
| D | GLY174 |
| D | VAL175 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KvEsrn.PSfSVKcRiGanM |
| Chain | Residue | Details |
| A | LYS30-MET48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:11023792 |
| Chain | Residue | Details |
| A | SER8 | |
| B | SER8 | |
| C | SER8 | |
| D | SER8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000305|PubMed:11023792 |
| Chain | Residue | Details |
| A | ASN35 | |
| A | ALA269 | |
| B | ASN35 | |
| B | ALA269 | |
| C | ASN35 | |
| C | ALA269 | |
| D | ASN35 | |
| D | ALA269 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10452898, ECO:0000269|PubMed:11023792, ECO:0000269|PubMed:9761678 |
| Chain | Residue | Details |
| A | THR72 | |
| A | SER273 | |
| B | THR72 | |
| B | SER273 | |
| C | THR72 | |
| C | SER273 | |
| D | THR72 | |
| D | SER273 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR177 | |
| B | THR177 | |
| C | THR177 | |
| D | THR177 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | CYS42 | |
| B | CYS42 | |
| C | CYS42 | |
| D | CYS42 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| A | CYS42 | covalent catalysis, proton shuttle (general acid/base) |
| A | SER273 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| B | CYS42 | covalent catalysis, proton shuttle (general acid/base) |
| B | SER273 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| C | CYS42 | covalent catalysis, proton shuttle (general acid/base) |
| C | SER273 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| D | CYS42 | covalent catalysis, proton shuttle (general acid/base) |
| D | SER273 | electrostatic stabiliser |
