Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 993 |
| Chain | Residue |
| A | ASP124 |
| A | GLU199 |
| A | GLU201 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 994 |
| Chain | Residue |
| A | ASP285 |
| A | GLN329 |
| A | ASP378 |
| A | ASP427 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 995 |
| Chain | Residue |
| A | GLY192 |
| A | ASP194 |
| A | HOH834 |
| A | HOH837 |
| A | ASP158 |
| A | GLY190 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 996 |
| Chain | Residue |
| A | ASP175 |
| A | GLY176 |
| A | GLY178 |
| A | ASN180 |
| A | ASP198 |
| A | GLU201 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 997 |
| Chain | Residue |
| A | HIS168 |
| A | ASP170 |
| A | HIS183 |
| A | HIS196 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 998 |
| Chain | Residue |
| A | HIS218 |
| A | HIS222 |
| A | HIS228 |
| A | HTA900 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HTA A 900 |
| Chain | Residue |
| A | GLY179 |
| A | ASN180 |
| A | LEU181 |
| A | ALA182 |
| A | HIS218 |
| A | GLU219 |
| A | HIS222 |
| A | HIS228 |
| A | PRO238 |
| A | ASN239 |
| A | TYR240 |
| A | HOH505 |
| A | HOH531 |
| A | HOH559 |
| A | ZN998 |
Functional Information from PROSITE/UniProt
| site_id | PS00024 |
| Number of Residues | 16 |
| Details | HEMOPEXIN Hemopexin domain signature. ISvfWpqvPnGLQAAY |
| Chain | Residue | Details |
| A | ILE317-TYR332 | |
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
| Chain | Residue | Details |
| A | VAL215-LEU224 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 49 |
| Details | Repeat: {"description":"Hemopexin 1"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Hemopexin 2"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"Hemopexin 3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"Hemopexin 4"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8590015","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis"} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P03956","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by PKDCC","evidences":[{"source":"UniProtKB","id":"P03956","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET236 | |
| A | GLU219 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU219 | |
