1F9W

CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003777	molecular_function	microtubule motor activity
A	0005524	molecular_function	ATP binding
A	0007018	biological_process	microtubule-based movement
A	0008017	molecular_function	microtubule binding
B	0003777	molecular_function	microtubule motor activity
B	0005524	molecular_function	ATP binding
B	0007018	biological_process	microtubule-based movement
B	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 996

Chain	Residue
A	THR481
A	ADP998

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 997

Chain	Residue
B	THR481
B	ADP999

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 998

Chain	Residue
A	GLY477
A	SER478
A	GLY479
A	LYS480
A	THR481
A	PHE482
A	MG996
A	HOH1003
A	ARG392
A	ARG394
A	PRO395
A	GLN475
A	THR476

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP B 999

Chain	Residue
B	ARG392
B	ARG394
B	PRO395
B	GLN475
B	THR476
B	GLY477
B	SER478
B	GLY479
B	LYS480
B	THR481
B	PHE482
B	MG997
B	HOH1050

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:11387196, ECO:0007744|PDB:1F9V

Chain	Residue	Details
A	ASN386
B	THR694
A	ARG388
A	GLU454
A	LYS579
A	THR694
B	ASN386
B	ARG388
B	GLU454
B	LYS579

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11387196, ECO:0000269|PubMed:22734002, ECO:0000269|PubMed:9485302, ECO:0007744|PDB:1F9T, ECO:0007744|PDB:1F9U, ECO:0007744|PDB:1F9V, ECO:0007744|PDB:1F9W, ECO:0007744|PDB:3KAR, ECO:0007744|PDB:4ETP

Chain	Residue	Details
A	ARG392
B	LYS480
B	THR481
B	PHE482
A	GLY477
A	GLY479
A	LYS480
A	THR481
A	PHE482
B	ARG392
B	GLY477
B	GLY479

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:11387196, ECO:0007744|PDB:1F9W

Chain	Residue	Details
A	SER478
B	SER478

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22734002, ECO:0007744|PDB:4ETP

Chain	Residue	Details
A	GLU554
B	GLU554

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1goj

Chain	Residue	Details
A	GLY629

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1goj

Chain	Residue	Details
B	GLY629

---