1F9R

CRYSTAL STRUCTURE OF PLATELET FACTOR 4 MUTANT 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002548	biological_process	monocyte chemotaxis
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006935	biological_process	chemotaxis
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0008009	molecular_function	chemokine activity
A	0008201	molecular_function	heparin binding
A	0010628	biological_process	positive regulation of gene expression
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016525	biological_process	negative regulation of angiogenesis
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030168	biological_process	platelet activation
A	0030195	biological_process	negative regulation of blood coagulation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031012	cellular_component	extracellular matrix
A	0031093	cellular_component	platelet alpha granule lumen
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0042127	biological_process	regulation of cell population proliferation
A	0042832	biological_process	defense response to protozoan
A	0045236	molecular_function	CXCR chemokine receptor binding
A	0045347	biological_process	negative regulation of MHC class II biosynthetic process
A	0045651	biological_process	positive regulation of macrophage differentiation
A	0045653	biological_process	negative regulation of megakaryocyte differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048018	molecular_function	receptor ligand activity
A	0048248	molecular_function	CXCR3 chemokine receptor binding
A	0051873	biological_process	killing by host of symbiont cells
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0071222	biological_process	cellular response to lipopolysaccharide
A	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0002548	biological_process	monocyte chemotaxis
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006935	biological_process	chemotaxis
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0008009	molecular_function	chemokine activity
B	0008201	molecular_function	heparin binding
B	0010628	biological_process	positive regulation of gene expression
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0016525	biological_process	negative regulation of angiogenesis
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030168	biological_process	platelet activation
B	0030195	biological_process	negative regulation of blood coagulation
B	0030593	biological_process	neutrophil chemotaxis
B	0030595	biological_process	leukocyte chemotaxis
B	0031012	cellular_component	extracellular matrix
B	0031093	cellular_component	platelet alpha granule lumen
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0042127	biological_process	regulation of cell population proliferation
B	0042832	biological_process	defense response to protozoan
B	0045236	molecular_function	CXCR chemokine receptor binding
B	0045347	biological_process	negative regulation of MHC class II biosynthetic process
B	0045651	biological_process	positive regulation of macrophage differentiation
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048018	molecular_function	receptor ligand activity
B	0048248	molecular_function	CXCR3 chemokine receptor binding
B	0051873	biological_process	killing by host of symbiont cells
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0071222	biological_process	cellular response to lipopolysaccharide
B	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	0002548	biological_process	monocyte chemotaxis
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006935	biological_process	chemotaxis
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0008009	molecular_function	chemokine activity
C	0008201	molecular_function	heparin binding
C	0010628	biological_process	positive regulation of gene expression
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0016525	biological_process	negative regulation of angiogenesis
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030168	biological_process	platelet activation
C	0030195	biological_process	negative regulation of blood coagulation
C	0030593	biological_process	neutrophil chemotaxis
C	0030595	biological_process	leukocyte chemotaxis
C	0031012	cellular_component	extracellular matrix
C	0031093	cellular_component	platelet alpha granule lumen
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0042127	biological_process	regulation of cell population proliferation
C	0042832	biological_process	defense response to protozoan
C	0045236	molecular_function	CXCR chemokine receptor binding
C	0045347	biological_process	negative regulation of MHC class II biosynthetic process
C	0045651	biological_process	positive regulation of macrophage differentiation
C	0045653	biological_process	negative regulation of megakaryocyte differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048018	molecular_function	receptor ligand activity
C	0048248	molecular_function	CXCR3 chemokine receptor binding
C	0051873	biological_process	killing by host of symbiont cells
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0071222	biological_process	cellular response to lipopolysaccharide
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0002548	biological_process	monocyte chemotaxis
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006935	biological_process	chemotaxis
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
D	0008009	molecular_function	chemokine activity
D	0008201	molecular_function	heparin binding
D	0010628	biological_process	positive regulation of gene expression
D	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
D	0016525	biological_process	negative regulation of angiogenesis
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030168	biological_process	platelet activation
D	0030195	biological_process	negative regulation of blood coagulation
D	0030593	biological_process	neutrophil chemotaxis
D	0030595	biological_process	leukocyte chemotaxis
D	0031012	cellular_component	extracellular matrix
D	0031093	cellular_component	platelet alpha granule lumen
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0042127	biological_process	regulation of cell population proliferation
D	0042832	biological_process	defense response to protozoan
D	0045236	molecular_function	CXCR chemokine receptor binding
D	0045347	biological_process	negative regulation of MHC class II biosynthetic process
D	0045651	biological_process	positive regulation of macrophage differentiation
D	0045653	biological_process	negative regulation of megakaryocyte differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048018	molecular_function	receptor ligand activity
D	0048248	molecular_function	CXCR3 chemokine receptor binding
D	0051873	biological_process	killing by host of symbiont cells
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0071222	biological_process	cellular response to lipopolysaccharide
D	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00471
Number of Residues	45
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. ClCVkttsq.VrpRhItsLevikaGphCavpQLIatlkngrki.CLD

Chain	Residue	Details
A	CYS10-ASP54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06765","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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