Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG162 |
| A | APC171 |
| A | HOH212 |
| A | HOH226 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | APC171 |
| A | PH2181 |
| A | HOH216 |
| A | ASP95 |
| A | ASP97 |
| A | MG161 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 163 |
| Chain | Residue |
| A | LYS119 |
| A | PHE137 |
| A | PRO138 |
| A | ASP139 |
| A | HOH219 |
| A | HOH362 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE APC A 171 |
| Chain | Residue |
| A | GLN74 |
| A | ARG82 |
| A | ARG84 |
| A | TRP89 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| A | THR112 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | MG161 |
| A | MG162 |
| A | PH2181 |
| A | HOH212 |
| A | HOH215 |
| A | HOH216 |
| A | HOH226 |
| A | HOH254 |
| A | HOH255 |
| A | HOH342 |
| A | HOH351 |
| A | HOH363 |
| A | HOH421 |
| A | HOH448 |
| A | HOH505 |
| A | HOH594 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PH2 A 181 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | LEU45 |
| A | TYR53 |
| A | ASN55 |
| A | ASP95 |
| A | PHE123 |
| A | MG162 |
| A | APC171 |
| A | HOH205 |
| A | HOH216 |
| A | HOH244 |
| A | HOH380 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ALA92 | |
| A | ARG82 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | VAL83 | electrostatic stabiliser, hydrogen bond donor |
| A | THR93 | electrostatic stabiliser, hydrogen bond donor |
| A | LEU96 | metal ligand |
| A | ILE98 | metal ligand |
