1F5Z
CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019262 | biological_process | N-acetylneuraminate catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. VdGLYvGGstgenfmLstEekkeifR |
| Chain | Residue | Details |
| A | VAL39-ARG64 |
| site_id | PS00228 |
| Number of Residues | 4 |
| Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MRDL |
| Chain | Residue | Details |
| A | MET1-LEU4 |
| site_id | PS00665 |
| Number of Residues | 18 |
| Details | DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGENfmlsteE |
| Chain | Residue | Details |
| A | GLY41-GLU58 |
| site_id | PS00666 |
| Number of Residues | 31 |
| Details | DHDPS_2 Dihydrodipicolinate synthase signature 2. YSIPflTgvnMgieqfgelyknpk.VlGVKFT |
| Chain | Residue | Details |
| A | TYR136-THR166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 |
| Chain | Residue | Details |
| A | TYR136 | |
| B | TYR136 | |
| C | TYR136 | |
| D | TYR136 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 |
| Chain | Residue | Details |
| A | LYS164 | |
| B | LYS164 | |
| C | LYS164 | |
| D | LYS164 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01237 |
| Chain | Residue | Details |
| A | SER47 | |
| B | THR166 | |
| B | GLY188 | |
| B | ASP190 | |
| B | GLU191 | |
| B | SER207 | |
| C | SER47 | |
| C | THR48 | |
| C | THR166 | |
| C | GLY188 | |
| C | ASP190 | |
| A | THR48 | |
| C | GLU191 | |
| C | SER207 | |
| D | SER47 | |
| D | THR48 | |
| D | THR166 | |
| D | GLY188 | |
| D | ASP190 | |
| D | GLU191 | |
| D | SER207 | |
| A | THR166 | |
| A | GLY188 | |
| A | ASP190 | |
| A | GLU191 | |
| A | SER207 | |
| B | SER47 | |
| B | THR48 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| A | TYR136 | |
| A | LYS164 | |
| A | LEU141 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| B | TYR136 | |
| B | LYS164 | |
| B | LEU141 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| C | TYR136 | |
| C | LYS164 | |
| C | LEU141 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| D | TYR136 | |
| D | LYS164 | |
| D | LEU141 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| A | THR48 | |
| A | LYS164 | |
| A | SER47 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| B | THR48 | |
| B | LYS164 | |
| B | SER47 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| C | THR48 | |
| C | LYS164 | |
| C | SER47 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| D | THR48 | |
| D | LYS164 | |
| D | SER47 |
