1F5A

CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	1990817	molecular_function	poly(A) RNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 1001

Chain	Residue
A	ASP113
A	ASP115
A	ASP167
A	3AT1000
A	MN1002
A	HOH2155
A	3PO4000

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 1002

Chain	Residue
A	3AT1000
A	MN1001
A	MN1003
A	HOH2104
A	3PO4000
A	ASP113
A	ASP115

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 1003

Chain	Residue
A	3AT1000
A	MN1002
A	3PO4000

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE 3AT A 1000

Chain	Residue
A	PHE100
A	GLY101
A	SER102
A	THR109
A	ASP115
A	VAL154
A	LYS158
A	ASP167
A	LYS228
A	TYR237
A	GLY246
A	VAL247
A	MN1001
A	MN1002
A	MN1003
A	HOH2010
A	HOH2045
A	HOH2104
A	HOH2127
A	HOH2129
A	HOH2155
A	HOH2167
A	3PO4000

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO A 4000

Chain	Residue
A	ALA112
A	ASP113
A	3AT1000
A	MN1001
A	MN1002
A	MN1003
A	HOH2155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with RNA","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fa0

Chain	Residue	Details
A	LYS228

---