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1F45

HUMAN INTERLEUKIN-12

Functional Information from GO Data
ChainGOidnamespacecontents
A0001817biological_processregulation of cytokine production
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002230biological_processpositive regulation of defense response to virus by host
A0002323biological_processnatural killer cell activation involved in immune response
A0002827biological_processpositive regulation of T-helper 1 type immune response
A0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004896molecular_functioncytokine receptor activity
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005143molecular_functioninterleukin-12 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0007166biological_processcell surface receptor signaling pathway
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010033biological_processresponse to organic substance
A0010224biological_processresponse to UV-B
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0019221biological_processcytokine-mediated signaling pathway
A0019953biological_processsexual reproduction
A0019955molecular_functioncytokine binding
A0030101biological_processnatural killer cell activation
A0031906cellular_componentlate endosome lumen
A0032693biological_processnegative regulation of interleukin-10 production
A0032700biological_processnegative regulation of interleukin-17 production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032816biological_processpositive regulation of natural killer cell activation
A0032819biological_processpositive regulation of natural killer cell proliferation
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034105biological_processpositive regulation of tissue remodeling
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035722biological_processinterleukin-12-mediated signaling pathway
A0042088biological_processT-helper 1 type immune response
A0042093biological_processT-helper cell differentiation
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0042164molecular_functioninterleukin-12 alpha subunit binding
A0042509biological_processregulation of tyrosine phosphorylation of STAT protein
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0042832biological_processdefense response to protozoan
A0043235cellular_componentreceptor complex
A0043382biological_processpositive regulation of memory T cell differentiation
A0043514cellular_componentinterleukin-12 complex
A0044877molecular_functionprotein-containing complex binding
A0045519molecular_functioninterleukin-23 receptor binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0046982molecular_functionprotein heterodimerization activity
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050671biological_processpositive regulation of lymphocyte proliferation
A0050709biological_processnegative regulation of protein secretion
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051135biological_processpositive regulation of NK T cell activation
A0051142biological_processpositive regulation of NK T cell proliferation
A0051607biological_processdefense response to virus
A0070743cellular_componentinterleukin-23 complex
A0071222biological_processcellular response to lipopolysaccharide
A0071346biological_processcellular response to type II interferon
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A2000318biological_processpositive regulation of T-helper 17 type immune response
A2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
B0005125molecular_functioncytokine activity
B0005143molecular_functioninterleukin-12 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0006955biological_processimmune response
B0008083molecular_functiongrowth factor activity
B0009615biological_processresponse to virus
B0010224biological_processresponse to UV-B
B0016477biological_processcell migration
B0031906cellular_componentlate endosome lumen
B0032496biological_processresponse to lipopolysaccharide
B0032700biological_processnegative regulation of interleukin-17 production
B0032729biological_processpositive regulation of type II interferon production
B0032816biological_processpositive regulation of natural killer cell activation
B0032946biological_processpositive regulation of mononuclear cell proliferation
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0035722biological_processinterleukin-12-mediated signaling pathway
B0042163molecular_functioninterleukin-12 beta subunit binding
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0043514cellular_componentinterleukin-12 complex
B0045513molecular_functioninterleukin-27 binding
B0045785biological_processpositive regulation of cell adhesion
B0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
B0046982molecular_functionprotein heterodimerization activity
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050671biological_processpositive regulation of lymphocyte proliferation
B0050709biological_processnegative regulation of protein secretion
B0050830biological_processdefense response to Gram-positive bacterium
B0051135biological_processpositive regulation of NK T cell activation
B0097191biological_processextrinsic apoptotic signaling pathway
B0098586biological_processcellular response to virus
B1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
B1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B2000510biological_processpositive regulation of dendritic cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV
ChainResidueDetails
AILE211-VAL253

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN71
BASN84

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108
ChainResidueDetails
AASN200

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176
ChainResidueDetails
ATRP297

218500

PDB entries from 2024-04-17

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