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1F3M

CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004674molecular_functionprotein serine/threonine kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
C0004672molecular_functionprotein kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD A 601
ChainResidue
AASN132

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IOD C 602
ChainResidue
CASN468
CLEU470
CIOD616

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD D 603
ChainResidue
DHOH631

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IOD D 604
ChainResidue
DPRO325
DIOD628

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD A 605
ChainResidue
CHOH653

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD A 607
ChainResidue
ALYS114

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IOD B 608
ChainResidue
AGLN102
AHOH667
BGLY98

site_idAC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD C 609
ChainResidue
CHOH628

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IOD C 610
ChainResidue
CASN466
DLYS268

site_idBC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD C 611
ChainResidue
CGLY364

site_idBC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD C 613
ChainResidue
CPRO325

site_idBC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IOD A 614
ChainResidue
ALYS119
BIOD615
BHOH652

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE IOD B 615
ChainResidue
AASN120
AIOD614
BLYS119
CHOH695

site_idBC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IOD C 616
ChainResidue
AHOH640
CIOD602
CHOH629

site_idBC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD B 617
ChainResidue
BHOH660

site_idBC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD D 619
ChainResidue
DMET399

site_idBC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD A 620
ChainResidue
ALYS134

site_idBC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD D 621
ChainResidue
DGLY364

site_idCC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD D 622
ChainResidue
DASP265

site_idCC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD C 623
ChainResidue
CLYS444

site_idCC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD B 624
ChainResidue
BHOH631

site_idCC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IOD D 625
ChainResidue
CLEU347
DASP400

site_idCC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IOD C 627
ChainResidue
CGLU514
CHOH701

site_idCC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IOD D 628
ChainResidue
DLYS323
DASN324
DIOD604

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL
ChainResidueDetails
CVAL385-LEU397

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by OXSR1","evidences":[{"source":"UniProtKB","id":"P35465","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17989089","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"20417602","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22153498","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22153498","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by JAK2","evidences":[{"source":"PubMed","id":"17726028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17989089","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis, BRSK2 and PDPK1","evidences":[{"source":"PubMed","id":"10551809","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10995762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22153498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22669945","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP393
CASP389

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP393
DASP389

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS391
CASP389

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DLYS391
DASP389

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS391
CASP389
CTHR427

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DLYS391
DASP389
DTHR427

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS391
CASP389
CASN394

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DLYS391
DASP389
DASN394

243083

PDB entries from 2025-10-15

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