1F3B
CRYSTAL STRUCTURE OF MGSTA1-1 IN COMPLEX WITH GLUTATHIONE CONJUGATE OF BENZO[A]PYRENE EPOXIDE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0004769 | molecular_function | steroid Delta-isomerase activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0009617 | biological_process | response to bacterium |
| A | 0035634 | biological_process | response to stilbenoid |
| A | 0035731 | molecular_function | dinitrosyl-iron complex binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0061771 | biological_process | response to caloric restriction |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 1901687 | biological_process | glutathione derivative biosynthetic process |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0004769 | molecular_function | steroid Delta-isomerase activity |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0009617 | biological_process | response to bacterium |
| B | 0035634 | biological_process | response to stilbenoid |
| B | 0035731 | molecular_function | dinitrosyl-iron complex binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043295 | molecular_function | glutathione binding |
| B | 0061771 | biological_process | response to caloric restriction |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 1901687 | biological_process | glutathione derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GBX A 223 |
| Chain | Residue |
| A | TYR8 |
| A | ALA215 |
| A | ARG216 |
| A | PHE219 |
| A | ILE221 |
| A | HOH405 |
| A | HOH442 |
| A | HOH546 |
| A | HOH685 |
| A | HOH776 |
| A | HOH814 |
| A | PHE9 |
| B | ASP100 |
| B | ARG130 |
| B | HOH331 |
| A | ARG14 |
| A | LYS44 |
| A | ASP52 |
| A | GLN53 |
| A | VAL54 |
| A | GLN66 |
| A | THR67 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GBX B 224 |
| Chain | Residue |
| A | ASP100 |
| A | ARG130 |
| A | HOH352 |
| B | TYR8 |
| B | PHE9 |
| B | ARG14 |
| B | LYS44 |
| B | GLN53 |
| B | VAL54 |
| B | PRO55 |
| B | GLN66 |
| B | THR67 |
| B | ALA215 |
| B | ARG216 |
| B | PHE219 |
| B | ILE221 |
| B | HOH338 |
| B | HOH389 |
| B | HOH432 |
| B | HOH538 |
| B | HOH681 |
| B | HOH784 |
| B | HOH812 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11027134","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11027134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR8 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | TYR8 |
