1F3A
CRYSTAL STRUCTURE OF MGSTA1-1 IN COMPLEX WITH GSH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0004769 | molecular_function | steroid Delta-isomerase activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0009617 | biological_process | response to bacterium |
| A | 0035634 | biological_process | response to stilbenoid |
| A | 0035731 | molecular_function | dinitrosyl-iron complex binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0061771 | biological_process | response to caloric restriction |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 1901687 | biological_process | glutathione derivative biosynthetic process |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0004769 | molecular_function | steroid Delta-isomerase activity |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0009617 | biological_process | response to bacterium |
| B | 0035634 | biological_process | response to stilbenoid |
| B | 0035731 | molecular_function | dinitrosyl-iron complex binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043295 | molecular_function | glutathione binding |
| B | 0061771 | biological_process | response to caloric restriction |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 1901687 | biological_process | glutathione derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GSH A 224 |
| Chain | Residue |
| A | TYR8 |
| A | HOH498 |
| A | HOH503 |
| A | HOH611 |
| A | HOH686 |
| A | HOH754 |
| B | ASP100 |
| B | ARG130 |
| B | HOH422 |
| A | ARG14 |
| A | LYS44 |
| A | GLN53 |
| A | VAL54 |
| A | PRO55 |
| A | GLN66 |
| A | THR67 |
| A | HOH382 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GSH B 226 |
| Chain | Residue |
| A | ASP100 |
| A | ARG130 |
| B | ARG14 |
| B | LYS44 |
| B | ASP52 |
| B | GLN53 |
| B | VAL54 |
| B | PRO55 |
| B | GLN66 |
| B | THR67 |
| B | HOH345 |
| B | HOH464 |
| B | HOH598 |
| B | HOH636 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 246 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11027134","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11027134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR8 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | TYR8 |
