1F2O

CRYSTAL STRUCTURE OF THE STREPTOMYCES GRISEUS AMINOPEPTIDASE COMPLEXED WITH L-LEUCINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008235	molecular_function	metalloexopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	HIS85
A	ASP97
A	ASP160
A	LEU903

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 902

Chain	Residue
A	ASP97
A	GLU132
A	HIS247
A	LEU903

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 905

Chain	Residue
A	ILE4
A	ASP262
A	ASP266
A	HOH349
A	HOH519
A	ASP3

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LEU A 903

Chain	Residue
A	HIS85
A	ASP97
A	GLU131
A	GLU132
A	ASP160
A	GLY199
A	ARG202
A	TYR246
A	HIS247
A	ZN901
A	ZN902

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15280041","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"17608735","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15388919","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9048953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"15280041","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"17608735","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
A	GLU131

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