Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0006707 | biological_process | cholesterol catabolic process |
A | 0008395 | molecular_function | steroid hydroxylase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0102199 | molecular_function | nitric oxide reductase (NAD(P)H) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEM A 501 |
Chain | Residue |
A | PHE86 |
A | MET244 |
A | SER286 |
A | GLY344 |
A | PHE345 |
A | GLY346 |
A | PHE347 |
A | HIS350 |
A | CYS352 |
A | ALA354 |
A | NO502 |
A | VAL87 |
A | HOH608 |
A | HOH612 |
A | HOH613 |
A | HIS94 |
A | ARG98 |
A | ILE153 |
A | LEU236 |
A | ALA239 |
A | GLY240 |
A | VAL243 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO A 502 |
Chain | Residue |
A | ALA239 |
A | GLY240 |
A | VAL243 |
A | HEM501 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 503 |
Chain | Residue |
A | ALA55 |
A | LYS62 |
A | MET89 |
A | ASP90 |
A | HIS350 |
A | HOH610 |
A | HOH641 |
A | HOH668 |
A | HOH870 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGDHRCIA |
Chain | Residue | Details |
A | PHE345-ALA354 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | ILE353 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 473 |
Chain | Residue | Details |
A | MET244 | steric role |
A | ALA287 | proton shuttle (general acid/base) |
A | ILE353 | activator, metal ligand |
A | VAL394 | proton shuttle (general acid/base) |