1F20

CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE FAD A 1501

Chain	Residue
A	HIS1032
A	TYR1197
A	GLY1209
A	VAL1210
A	CYS1211
A	SER1212
A	ARG1229
A	THR1251
A	LYS1371
A	LEU1372
A	PHE1395
A	ARG1173
A	GLY1396
A	HOH1612
A	HOH1613
A	HOH1614
A	HOH1616
A	HOH1697
A	HOH1805
A	HOH2024
A	HOH2025
A	TYR1174
A	TYR1175
A	SER1176
A	THR1191
A	VAL1192
A	ALA1193
A	VAL1195

---

site_id	AC2
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAP A 1502

Chain	Residue
A	ARG1010
A	ALA1193
A	VAL1195
A	GLY1250
A	THR1251
A	CYS1283
A	ARG1284
A	SER1313
A	ARG1314
A	TYR1322
A	GLN1324
A	ASP1351
A	MET1354
A	ASP1357
A	ARG1383
A	HOH1627
A	HOH1628
A	HOH1643
A	HOH1660
A	HOH1678
A	HOH1684
A	HOH1696
A	HOH1698
A	HOH1704
A	HOH1706
A	HOH1719
A	HOH1738
A	HOH1845
A	HOH1903
A	HOH2032
A	HOH2069
A	GOL2080
A	GOL2082

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2080

Chain	Residue
A	TYR1322
A	PHE1380
A	ASP1387
A	ARG1389
A	NAP1502
A	HOH1679
A	HOH1684
A	HOH1685
A	GOL2083

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2081

Chain	Residue
A	PRO978
A	ASP979
A	LEU980
A	GLN1092
A	TYR1097
A	HOH1661
A	HOH1785

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 2082

Chain	Residue
A	ARG1010
A	ARG1284
A	LEU1372
A	NAP1502
A	HOH1683
A	HOH1685
A	HOH1688
A	HOH1706

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2083

Chain	Residue
A	GLN1324
A	ASP1357
A	ASP1387
A	HOH1689
A	HOH1734
A	HOH1736
A	GOL2080

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2084

Chain	Residue
A	HOH1876
A	HOH2043
A	LYS1095
A	TRP1214
A	ARG1217
A	ASP1222
A	HOH1828
A	HOH1857
A	HOH1859

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 2085

Chain	Residue
A	GLN1028
A	ASP1031
A	HOH1906

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 2086

Chain	Residue
A	GLN1342
A	GLY1343
A	LYS1360
A	HOH2042

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 2087

Chain	Residue
A	SER1286
A	LYS1287
A	ILE1288
A	ASP1289
A	HIS1290
A	HOH1881
A	HOH2079

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	247
Details	Domain: {"description":"FAD-binding FR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00716","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11473123","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15208315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F20","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TLL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15208315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TLL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11473123","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F20","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1fnb

Chain	Residue	Details
A	CYS1349
A	SER1176
A	ASP1393

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fnb

Chain	Residue	Details
A	TYR1175

---