1EZR

CRYSTAL STRUCTURE OF NUCLEOSIDE HYDROLASE FROM LEISHMANIA MAJOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0008477	molecular_function	purine nucleosidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0043101	biological_process	purine-containing compound salvage
A	0045437	molecular_function	uridine nucleosidase activity
A	0046872	molecular_function	metal ion binding
A	0047724	molecular_function	inosine nucleosidase activity
B	0005509	molecular_function	calcium ion binding
B	0008477	molecular_function	purine nucleosidase activity
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
B	0043101	biological_process	purine-containing compound salvage
B	0045437	molecular_function	uridine nucleosidase activity
B	0046872	molecular_function	metal ion binding
B	0047724	molecular_function	inosine nucleosidase activity
C	0005509	molecular_function	calcium ion binding
C	0008477	molecular_function	purine nucleosidase activity
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0043101	biological_process	purine-containing compound salvage
C	0045437	molecular_function	uridine nucleosidase activity
C	0046872	molecular_function	metal ion binding
C	0047724	molecular_function	inosine nucleosidase activity
D	0005509	molecular_function	calcium ion binding
D	0008477	molecular_function	purine nucleosidase activity
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
D	0043101	biological_process	purine-containing compound salvage
D	0045437	molecular_function	uridine nucleosidase activity
D	0046872	molecular_function	metal ion binding
D	0047724	molecular_function	inosine nucleosidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 401

Chain	Residue
A	ASP10
A	ASP15
A	THR126
A	ASP241

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 401

Chain	Residue
B	ASP10
B	ASP15
B	THR126
B	ASP241

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 401

Chain	Residue
C	ASP15
C	THR126
C	ASP241
C	ASP10

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 401

Chain	Residue
D	ASP10
D	ASP15
D	THR126
D	ASP241

---

Functional Information from PROSITE/UniProt

site_id	PS01247
Number of Residues	11
Details	IUNH Inosine-uridine preferring nucleoside hydrolase family signature. DcDPGiDDAVA

Chain	Residue	Details
A	ASP8-ALA18

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q27546","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1mas

Chain	Residue	Details
A	ASP10
A	HIS240
A	ASN168

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1mas

Chain	Residue	Details
B	ASP10
B	HIS240
B	ASN168

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1mas

Chain	Residue	Details
C	ASP10
C	HIS240
C	ASN168

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1mas

Chain	Residue	Details
D	ASP10
D	HIS240
D	ASN168

---