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1EXW

CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1 COMPLEXED WITH HEXADECYLSULFONYL FLUORIDE

Functional Information from GO Data
ChainGOidnamespacecontents
A0002084biological_processprotein depalmitoylation
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005764cellular_componentlysosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006897biological_processendocytosis
A0006898biological_processreceptor-mediated endocytosis
A0006907biological_processpinocytosis
A0007042biological_processlysosomal lumen acidification
A0007399biological_processnervous system development
A0007420biological_processbrain development
A0008021cellular_componentsynaptic vesicle
A0008474molecular_functionpalmitoyl-(protein) hydrolase activity
A0015031biological_processprotein transport
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0030308biological_processnegative regulation of cell growth
A0030424cellular_componentaxon
A0031579biological_processmembrane raft organization
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045121cellular_componentmembrane raft
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0048549biological_processpositive regulation of pinocytosis
A0052816molecular_functionlong-chain fatty acyl-CoA hydrolase activity
A0098599molecular_functionpalmitoyl hydrolase activity
A0120146molecular_functionsulfatide binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:10781062
ChainResidueDetails
ASER115
AASP233
AHIS289

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN197
AASN212
AASN232

Catalytic Information from CSA
site_idCSA1
Number of Residues5
DetailsAnnotated By Reference To The Literature 1eh5
ChainResidueDetails
AGLN116
AHIS289
AASP233
ASER115
AMET41

site_idMCSA1
Number of Residues5
DetailsM-CSA 522
ChainResidueDetails
AMET41electrostatic stabiliser
ASER115covalently attached, electrostatic stabiliser, proton shuttle (general acid/base)
AGLN116electrostatic stabiliser
AASP233electrostatic stabiliser
AHIS289electrostatic stabiliser, proton shuttle (general acid/base)

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PDB entries from 2024-11-13

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