1EXN
T5 5'-EXONUCLEASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004529 | molecular_function | DNA exonuclease activity |
| A | 0006260 | biological_process | DNA replication |
| A | 0008409 | molecular_function | 5'-3' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0017108 | molecular_function | 5'-flap endonuclease activity |
| A | 0019034 | cellular_component | viral replication complex |
| A | 0019086 | biological_process | late viral transcription |
| A | 0033567 | biological_process | DNA replication, Okazaki fragment processing |
| A | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| A | 0039693 | biological_process | viral DNA genome replication |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048256 | molecular_function | flap endonuclease activity |
| A | 0051908 | molecular_function | double-stranded DNA 5'-3' DNA exonuclease activity |
| A | 1990238 | molecular_function | double-stranded DNA endonuclease activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0004529 | molecular_function | DNA exonuclease activity |
| B | 0006260 | biological_process | DNA replication |
| B | 0008409 | molecular_function | 5'-3' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0017108 | molecular_function | 5'-flap endonuclease activity |
| B | 0019034 | cellular_component | viral replication complex |
| B | 0019086 | biological_process | late viral transcription |
| B | 0033567 | biological_process | DNA replication, Okazaki fragment processing |
| B | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| B | 0039693 | biological_process | viral DNA genome replication |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048256 | molecular_function | flap endonuclease activity |
| B | 0051908 | molecular_function | double-stranded DNA 5'-3' DNA exonuclease activity |
| B | 1990238 | molecular_function | double-stranded DNA endonuclease activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Region: {"description":"Helical arch","evidences":[{"source":"HAMAP-Rule","id":"MF_04140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27273516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8657312","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10364212","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27273516","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15077103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27273516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8657312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 9874768, 16600865, 18697748 |
| Chain | Residue | Details |
| A | LYS83 | |
| A | ARG86 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 549 |
| Chain | Residue | Details |
| A | PHE34 | metal ligand |
| A | PHE224 | metal ligand |
| A | LEU76 | metal ligand |
| A | ALA91 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | THR94 | electrostatic stabiliser |
| A | ILE136 | metal ligand |
| A | LEU139 | metal ligand |
| A | SER165 | metal ligand |
| A | PHE167 | metal ligand |
| A | ILE221 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 10 |
| Details | M-CSA 549 |
| Chain | Residue | Details |
| B | PHE34 | metal ligand |
| B | PHE224 | metal ligand |
| B | LEU76 | metal ligand |
| B | ALA91 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | THR94 | electrostatic stabiliser |
| B | ILE136 | metal ligand |
| B | LEU139 | metal ligand |
| B | SER165 | metal ligand |
| B | PHE167 | metal ligand |
| B | ILE221 | metal ligand |
