1EV4

RAT GLUTATHIONE S-TRANSFERASE A1-1: MUTANT W21F/F220Y WITH GSO3 BOUND

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004769	molecular_function	steroid delta-isomerase activity
A	0005504	molecular_function	fatty acid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0030855	biological_process	epithelial cell differentiation
A	0031667	biological_process	response to nutrient levels
A	0035731	molecular_function	dinitrosyl-iron complex binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0043651	biological_process	linoleic acid metabolic process
A	0098869	biological_process	cellular oxidant detoxification
A	1901687	biological_process	glutathione derivative biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0004601	molecular_function	peroxidase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0004769	molecular_function	steroid delta-isomerase activity
C	0005504	molecular_function	fatty acid binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0009410	biological_process	response to xenobiotic stimulus
C	0016740	molecular_function	transferase activity
C	0016853	molecular_function	isomerase activity
C	0030855	biological_process	epithelial cell differentiation
C	0031667	biological_process	response to nutrient levels
C	0035731	molecular_function	dinitrosyl-iron complex binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0043295	molecular_function	glutathione binding
C	0043651	biological_process	linoleic acid metabolic process
C	0098869	biological_process	cellular oxidant detoxification
C	1901687	biological_process	glutathione derivative biosynthetic process
D	0004364	molecular_function	glutathione transferase activity
D	0004601	molecular_function	peroxidase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0004769	molecular_function	steroid delta-isomerase activity
D	0005504	molecular_function	fatty acid binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0009410	biological_process	response to xenobiotic stimulus
D	0016740	molecular_function	transferase activity
D	0016853	molecular_function	isomerase activity
D	0030855	biological_process	epithelial cell differentiation
D	0031667	biological_process	response to nutrient levels
D	0035731	molecular_function	dinitrosyl-iron complex binding
D	0042178	biological_process	xenobiotic catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0043295	molecular_function	glutathione binding
D	0043651	biological_process	linoleic acid metabolic process
D	0098869	biological_process	cellular oxidant detoxification
D	1901687	biological_process	glutathione derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 260

Chain	Residue
A	THR77
A	ASP85
A	MET86
A	ARG89
A	HOH537

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 261

Chain	Residue
C	ASP85
C	MET86
C	ARG89

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 262

Chain	Residue
D	ASP85
D	MET86
D	ARG89
C	THR77

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTS A 230

Chain	Residue
A	TYR9
A	ARG15
A	LYS45
A	GLN54
A	VAL55
A	GLN67
A	THR68
A	ASP101
A	ARG127
A	ARG131
A	TYR220
A	LYS221
A	HOH459
A	HOH518
A	HOH687
A	HOH742

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTS C 240

Chain	Residue
C	TYR9
C	PHE10
C	ARG15
C	LYS45
C	ASP53
C	GLN54
C	VAL55
C	GLN67
C	THR68
D	ASP101
D	ARG131
D	HOH604

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTS D 250

Chain	Residue
C	ASP101
C	ARG131
D	TYR9
D	ARG15
D	LYS45
D	GLN54
D	VAL55
D	PRO56
D	GLN67
D	THR68
D	HOH503
D	HOH617
D	HOH792

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11119643

Chain	Residue	Details
A	PHE10
D	LYS46
D	VAL55
D	THR68
A	LYS46
A	VAL55
A	THR68
C	PHE10
C	LYS46
C	VAL55
C	THR68
D	PHE10

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P80894

Chain	Residue	Details
A	SER2
C	SER2
D	SER2

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P30115

Chain	Residue	Details
A	PRO5
C	PRO5
D	PRO5

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR9

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
C	TYR9

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
D	TYR9

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