1EUS
SIALIDASE COMPLEXED WITH 2-DEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
Functional Information from PDB Data
| site_id | ACT |
| Number of Residues | 6 |
| Details | ACTIVE SITE. SITE COMPRISES BOTH THE SIX RESIDUES INDICATED IN THE 'SITE' RECORDS AND THE CORRESPONDING RESIDUES OF AN SYMMETRY-RELATED UNIT. |
| Chain | Residue |
| A | GLN224 |
| A | GLY245 |
| A | ALA250 |
| A | GLY292 |
| A | ASN311 |
| A | PHE318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP92 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU260 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | TYR370 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG68 | |
| A | ARG276 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1euu |
| Chain | Residue | Details |
| A | ASP92 | |
| A | TYR370 | |
| A | GLU260 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 835 |
| Chain | Residue | Details |
| A | ASP92 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | GLU260 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | TYR370 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
