1ETB

THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0001523	biological_process	retinoid metabolic process
1	0005179	molecular_function	hormone activity
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005615	cellular_component	extracellular space
1	0005737	cellular_component	cytoplasm
1	0006144	biological_process	purine nucleobase metabolic process
1	0007165	biological_process	signal transduction
1	0032991	cellular_component	protein-containing complex
1	0035578	cellular_component	azurophil granule lumen
1	0042562	molecular_function	hormone binding
1	0042802	molecular_function	identical protein binding
1	0044877	molecular_function	protein-containing complex binding
1	0070062	cellular_component	extracellular exosome
1	0140313	molecular_function	molecular sequestering activity
2	0001523	biological_process	retinoid metabolic process
2	0005179	molecular_function	hormone activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0005737	cellular_component	cytoplasm
2	0006144	biological_process	purine nucleobase metabolic process
2	0007165	biological_process	signal transduction
2	0032991	cellular_component	protein-containing complex
2	0035578	cellular_component	azurophil granule lumen
2	0042562	molecular_function	hormone binding
2	0042802	molecular_function	identical protein binding
2	0044877	molecular_function	protein-containing complex binding
2	0070062	cellular_component	extracellular exosome
2	0140313	molecular_function	molecular sequestering activity

Functional Information from PDB Data

site_id	AA
Number of Residues	7
Details	T4 BINDING SITE COMPOSED OF RESIDUES FROM CHAIN 1 AND ITS 2-FOLD SYMMETRIC CHAIN. ONLY THE RESIDUES FROM CHAIN 1 ARE LISTED HERE

Chain	Residue
1	LYS15
1	GLU54
1	LEU17
1	ALA108
1	THR109
1	LEU110
1	SER117

---

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE T44 1 128

Chain	Residue
1	MET13
1	LYS15
1	LEU17
1	LEU17
1	GLU54
1	ALA108
1	THR109
1	LEU110
1	LEU110
1	HOH215

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE T44 2 129

Chain	Residue
2	LYS15
2	LEU17
2	GLU54
2	ALA108
2	THR109
2	LEU110
2	HOH211

---

site_id	BB
Number of Residues	7
Details	T4 BINDING SITE COMPOSED OF RESIDUES FROM CHAIN 2 AND ITS 2-FOLD SYMMETRIC CHAIN. ONLY THE RESIDUES FROM CHAIN 1 ARE LISTED HERE

Chain	Residue
2	LEU17
2	ALA108
2	THR109
2	LEU110
2	SER117
2	LYS15
2	GLU54

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
1	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAtlLSPYSYS

Chain	Residue	Details
1	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---