1ETB

THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005179	molecular_function	hormone activity
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005615	cellular_component	extracellular space
1	0005737	cellular_component	cytoplasm
1	0006144	biological_process	purine nucleobase metabolic process
1	0007165	biological_process	signal transduction
1	0035578	cellular_component	azurophil granule lumen
1	0042802	molecular_function	identical protein binding
1	0070062	cellular_component	extracellular exosome
1	0070324	molecular_function	thyroid hormone binding
2	0005179	molecular_function	hormone activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0005737	cellular_component	cytoplasm
2	0006144	biological_process	purine nucleobase metabolic process
2	0007165	biological_process	signal transduction
2	0035578	cellular_component	azurophil granule lumen
2	0042802	molecular_function	identical protein binding
2	0070062	cellular_component	extracellular exosome
2	0070324	molecular_function	thyroid hormone binding

Functional Information from PDB Data

site_id	AA
Number of Residues	7
Details	T4 BINDING SITE COMPOSED OF RESIDUES FROM CHAIN 1 AND ITS 2-FOLD SYMMETRIC CHAIN. ONLY THE RESIDUES FROM CHAIN 1 ARE LISTED HERE

Chain	Residue
1	LYS15
1	GLU54
1	LEU17
1	ALA108
1	THR109
1	LEU110
1	SER117

---

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE T44 1 128

Chain	Residue
1	MET13
1	LYS15
1	LEU17
1	LEU17
1	GLU54
1	ALA108
1	THR109
1	LEU110
1	LEU110
1	HOH215

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE T44 2 129

Chain	Residue
2	LYS15
2	LEU17
2	GLU54
2	ALA108
2	THR109
2	LEU110
2	HOH211

---

site_id	BB
Number of Residues	7
Details	T4 BINDING SITE COMPOSED OF RESIDUES FROM CHAIN 2 AND ITS 2-FOLD SYMMETRIC CHAIN. ONLY THE RESIDUES FROM CHAIN 1 ARE LISTED HERE

Chain	Residue
2	LEU17
2	ALA108
2	THR109
2	LEU110
2	SER117
2	LYS15
2	GLU54

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
1	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAtlLSPYSYS

Chain	Residue	Details
1	TYR105-SER117

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT

Chain	Residue	Details
1	LYS15
1	GLU54
1	SER117
2	LYS15
2	GLU54
2	SER117

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E

Chain	Residue	Details
1	CYS10
2	CYS10

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012

Chain	Residue	Details
1	GLU42
2	GLU42

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767

Chain	Residue	Details
1	SER52
2	SER52

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329

Chain	Residue	Details
1	ASN98
2	ASN98

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