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1ESR

CRYSTAL STRUCTURE OF HUMAN MONOCYTE CHEMOTACTIC PROTEIN-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002548biological_processmonocyte chemotaxis
A0002687biological_processpositive regulation of leukocyte migration
A0004672molecular_functionprotein kinase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0008201molecular_functionheparin binding
A0009615biological_processresponse to virus
A0016004molecular_functionphospholipase activator activity
A0030335biological_processpositive regulation of cell migration
A0031727molecular_functionCCR2 chemokine receptor binding
A0044828biological_processnegative regulation by host of viral genome replication
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070664biological_processnegative regulation of leukocyte proliferation
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues43
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFnvinrk..IpiqrLesYtritniq.Cpke.AVIFktqrgkev.CA
ChainResidueDetails
ACYS11-ALA53

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:11087354
ChainResidueDetails
APCA1

222415

PDB entries from 2024-07-10

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