1ESJ

CRYSTAL STRUCTURE OF THIAZOLE KINASE MUTANT (C198S)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004417	molecular_function	hydroxyethylthiazole kinase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0008902	molecular_function	hydroxymethylpyrimidine kinase activity
A	0008972	molecular_function	phosphomethylpyrimidine kinase activity
A	0009228	biological_process	thiamine biosynthetic process
A	0009229	biological_process	thiamine diphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0018130	biological_process	heterocycle biosynthetic process
A	0019438	biological_process	aromatic compound biosynthetic process
A	0044271	biological_process	cellular nitrogen compound biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1901362	biological_process	organic cyclic compound biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004417	molecular_function	hydroxyethylthiazole kinase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0008902	molecular_function	hydroxymethylpyrimidine kinase activity
B	0008972	molecular_function	phosphomethylpyrimidine kinase activity
B	0009228	biological_process	thiamine biosynthetic process
B	0009229	biological_process	thiamine diphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0018130	biological_process	heterocycle biosynthetic process
B	0019438	biological_process	aromatic compound biosynthetic process
B	0044271	biological_process	cellular nitrogen compound biosynthetic process
B	0046872	molecular_function	metal ion binding
B	1901362	biological_process	organic cyclic compound biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004417	molecular_function	hydroxyethylthiazole kinase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0008902	molecular_function	hydroxymethylpyrimidine kinase activity
C	0008972	molecular_function	phosphomethylpyrimidine kinase activity
C	0009228	biological_process	thiamine biosynthetic process
C	0009229	biological_process	thiamine diphosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0018130	biological_process	heterocycle biosynthetic process
C	0019438	biological_process	aromatic compound biosynthetic process
C	0044271	biological_process	cellular nitrogen compound biosynthetic process
C	0046872	molecular_function	metal ion binding
C	1901362	biological_process	organic cyclic compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 315

Chain	Residue
A	THR194
A	GLY195
A	ALA196
A	GLY197
A	SER198

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 325

Chain	Residue
C	HOH489
C	HOH554
C	HOH634
C	THR194
C	GLY195
C	GLY197
C	SER198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00228, ECO:0000269|PubMed:10891066

Chain	Residue	Details
A	MET45
A	GLY195
B	MET45
B	GLY195
C	MET45
C	GLY195

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	ARG121
A	THR168
B	ARG121
B	THR168
C	ARG121
C	THR168

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