1EPZ

CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOASE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM WITH BOUND LIGAND.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A	0016853	molecular_function	isomerase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
A	0045226	biological_process	extracellular polysaccharide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TYD A 2187

Chain	Residue
A	TYR22
A	LYS171
A	HOH1035
A	HOH1036
A	HOH1037
A	HOH1040
A	HOH1095
A	ARG26
A	PHE29
A	GLU31
A	GLN49
A	ASN51
A	ARG61
A	HIS64
A	TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:10827167

Chain	Residue	Details
A	HIS64

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q9HU21

Chain	Residue	Details
A	TYR133

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9HU21

Chain	Residue	Details
A	ARG26
A	GLU31
A	LYS73
A	HIS120
A	ASP144
A	LYS171

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10827167, ECO:0007744|PDB:1EPZ

Chain	Residue	Details
A	GLN49
A	ARG61

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000250|UniProtKB:Q5SFD1

Chain	Residue	Details
A	TYR139

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
A	ASP172
A	HIS64

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