1EPM

A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PSA I 1

Chain	Residue
E	GLY217
I	ALA2
I	LEU2
I	GLN3
E	ASP30
E	ASP32
E	GLY34
E	TYR75
E	GLY76
E	ASP77
E	ASP215

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 327

Chain	Residue
E	LYS238
E	SER240
E	SER241
E	SER242

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 328

Chain	Residue
E	TYR175
E	SER178
E	ILE179
E	HOH589

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 329

Chain	Residue
E	SER108
E	SER109
E	THR318
E	THR319
E	HOH453
E	HOH500
E	HOH505
E	HOH538

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site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR CHAIN I OF PS2, THR-PHE-GLN-ALA-PSA-LEU-ARG-GLU

Chain	Residue
E	ASP12
E	THR219
E	LEU220
E	PHE275
E	PHE284
I	GLN3
I	ARG3
I	HOH7
I	HOH10
I	HOH12

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site_id	CAT
Number of Residues	2
Details	CATALYTIC RESIDUES

Chain	Residue
E	ASP32
E	ASP215

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
E	LEU29-VAL40
E	GLY212-LEU223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
E	ASP32
E	SER194

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	THR218
E	ASP32

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site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR216
E	ASP32
E	THR33

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site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	ASP32

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR218
E	ASP32
E	THR33

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