1ENT

X-RAY ANALYSES OF ASPARTIC PROTEINASES. THE THREE-DIMENSIONAL STRUCTURE AT 2.1 ANGSTROMS RESOLUTION OF ENDOTHIAPEPSIN

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0EM E 822

Chain	Residue
E	ASP32
E	ASP215
E	GLY217
E	THR218
E	THR219
E	ILE297
E	ILE301
E	HOH1087
E	GLY34
E	SER35
E	TYR75
E	GLY76
E	ASP77
E	ASP114
E	ILE117
E	PHE189

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 823

Chain	Residue
E	LYS238
E	SER240
E	SER241
E	SER242
E	HOH1013

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 824

Chain	Residue
E	SER108
E	SER109
E	THR318
E	THR319
E	HOH996
E	HOH1001
E	HOH1035

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site_id	CAT
Number of Residues	2
Details	CATALYTIC SITE

Chain	Residue
E	ASP32
E	ASP215

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
E	LEU29-VAL40
E	GLY212-LEU223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	311
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	THR218
E	ASP32

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR216
E	ASP32
E	THR33

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	ASP32

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR218
E	ASP32
E	THR33

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