1ELV
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE
Functional Information from GO Data
Functional Information from PDB Data
| site_id | CAT |
| Number of Residues | 3 |
| Details | THE CATALYTIC TRIAD IS: HIS A460 (57), ASP A514 (102), SER A617 (195) (RESIDUE NUMBERS IN THE REFERENCE CHYMOTRYPSINOGEN MOLECULE). |
| Chain | Residue |
| A | HIS460 |
| A | ASP514 |
| A | SER617 |
Functional Information from PROSITE/UniProt
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGAFA |
| Chain | Residue | Details |
| A | ASP611-ALA622 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"10775260","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12788922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP514 | |
| A | HIS460 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY618 | |
| A | SER617 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY615 | |
| A | SER617 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP514 | |
| A | SER617 | |
| A | HIS460 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP514 | |
| A | GLY618 | |
| A | SER617 | |
| A | HIS460 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY615 | |
| A | ASP514 | |
| A | SER639 | |
| A | SER617 | |
| A | HIS460 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY615 | |
| A | ASP514 | |
| A | SER617 | |
| A | HIS460 |
