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1EK9

2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0009279cellular_componentcell outer membrane
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0015125molecular_functionbile acid transmembrane transporter activity
A0015288molecular_functionporin activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015721biological_processbile acid and bile salt transport
A0016020cellular_componentmembrane
A0019867cellular_componentouter membrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042930biological_processenterobactin transport
A0042931molecular_functionenterobactin transmembrane transporter activity
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
A0098567cellular_componentperiplasmic side of plasma membrane
A0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
A1990196cellular_componentMacAB-TolC complex
A1990281cellular_componentefflux pump complex
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0009279cellular_componentcell outer membrane
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0015125molecular_functionbile acid transmembrane transporter activity
B0015288molecular_functionporin activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015721biological_processbile acid and bile salt transport
B0016020cellular_componentmembrane
B0019867cellular_componentouter membrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042930biological_processenterobactin transport
B0042931molecular_functionenterobactin transmembrane transporter activity
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
B0098567cellular_componentperiplasmic side of plasma membrane
B0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
B1990196cellular_componentMacAB-TolC complex
B1990281cellular_componentefflux pump complex
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0009279cellular_componentcell outer membrane
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0015125molecular_functionbile acid transmembrane transporter activity
C0015288molecular_functionporin activity
C0015562molecular_functionefflux transmembrane transporter activity
C0015721biological_processbile acid and bile salt transport
C0016020cellular_componentmembrane
C0019867cellular_componentouter membrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0042930biological_processenterobactin transport
C0042931molecular_functionenterobactin transmembrane transporter activity
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
C0098567cellular_componentperiplasmic side of plasma membrane
C0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
C1990196cellular_componentMacAB-TolC complex
C1990281cellular_componentefflux pump complex
C1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues33
DetailsTRANSMEM: Beta stranded; Name=S1
ChainResidueDetails
ALEU39-TYR50
BLEU39-TYR50
CLEU39-TYR50

site_idSWS_FT_FI2
Number of Residues81
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
ASER51-ASN58
AILE256-ASP276
BSER51-ASN58
BILE256-ASP276
CSER51-ASN58
CILE256-ASP276

site_idSWS_FT_FI3
Number of Residues39
DetailsTRANSMEM: Beta stranded; Name=S2
ChainResidueDetails
AGLY59-THR72
BGLY59-THR72
CGLY59-THR72

site_idSWS_FT_FI4
Number of Residues513
DetailsTOPO_DOM: Periplasmic
ChainResidueDetails
AGLN73-HIS244
BGLN73-HIS244
CGLN73-HIS244

site_idSWS_FT_FI5
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S4
ChainResidueDetails
ALEU245-GLY255
BLEU245-GLY255
CLEU245-GLY255

site_idSWS_FT_FI6
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S5
ChainResidueDetails
ASER277-SER287
BSER277-SER287
CSER277-SER287

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PDB entries from 2024-08-28

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