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1EJ4

COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE M7G A 1000
ChainResidue
ATRP56
AMET101
ATRP102
AGLU103
AARG157
ALYS159
ALYS162
AHOH1026
AHOH1070

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BTYR54
ATRP102
AARG157
ATHR205

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
ChainResidueDetails
BLYS57

226707

PDB entries from 2024-10-30

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