1EIX
STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
C | 0016831 | molecular_function | carboxy-lyase activity |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
D | 0016831 | molecular_function | carboxy-lyase activity |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE BMQ A 1301 |
Chain | Residue |
A | ALA20 |
A | GLN201 |
A | VAL219 |
A | GLY221 |
A | ARG222 |
A | HOH503 |
A | HOH506 |
A | HOH509 |
A | HOH511 |
A | HOH512 |
B | ASP76 |
A | ASP22 |
B | ILE77 |
B | THR80 |
A | LYS44 |
A | ASP71 |
A | LYS73 |
A | LEU130 |
A | THR131 |
A | PRO189 |
A | ARG192 |
site_id | AC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE BMQ B 1302 |
Chain | Residue |
A | ASP76 |
A | ILE77 |
A | THR80 |
B | ALA20 |
B | ASP22 |
B | LYS44 |
B | ASP71 |
B | LYS73 |
B | LEU130 |
B | THR131 |
B | PRO189 |
B | ARG192 |
B | GLN201 |
B | GLY221 |
B | ARG222 |
B | HOH523 |
B | HOH526 |
B | HOH529 |
B | HOH531 |
B | HOH532 |
site_id | AC3 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE BMQ C 1303 |
Chain | Residue |
C | ALA20 |
C | ASP22 |
C | LYS44 |
C | ASP71 |
C | LYS73 |
C | LEU130 |
C | THR131 |
C | PRO189 |
C | ARG192 |
C | GLN201 |
C | VAL219 |
C | GLY221 |
C | ARG222 |
C | HOH543 |
C | HOH546 |
C | HOH549 |
C | HOH551 |
C | HOH552 |
D | ASP76 |
D | ILE77 |
D | THR80 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE BMQ D 1304 |
Chain | Residue |
C | ASP76 |
C | ILE77 |
C | THR80 |
D | ALA20 |
D | ASP22 |
D | LYS44 |
D | ASP71 |
D | LYS73 |
D | LEU130 |
D | THR131 |
D | PRO189 |
D | ARG192 |
D | GLN201 |
D | VAL219 |
D | GLY221 |
D | ARG222 |
D | HOH563 |
D | HOH566 |
D | HOH569 |
D | HOH571 |
D | HOH572 |
Functional Information from PROSITE/UniProt
site_id | PS00156 |
Number of Residues | 14 |
Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFlDlKfhDIPnTA |
Chain | Residue | Details |
A | ILE68-ALA81 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | LYS73 | |
B | LYS73 | |
C | LYS73 | |
D | LYS73 |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP22 | |
B | LYS44 | |
B | ASP71 | |
B | THR131 | |
B | ARG192 | |
B | GLN201 | |
B | GLY221 | |
B | ARG222 | |
C | ASP22 | |
C | LYS44 | |
C | ASP71 | |
A | LYS44 | |
C | THR131 | |
C | ARG192 | |
C | GLN201 | |
C | GLY221 | |
C | ARG222 | |
D | ASP22 | |
D | LYS44 | |
D | ASP71 | |
D | THR131 | |
D | ARG192 | |
A | ASP71 | |
D | GLN201 | |
D | GLY221 | |
D | ARG222 | |
A | THR131 | |
A | ARG192 | |
A | GLN201 | |
A | GLY221 | |
A | ARG222 | |
B | ASP22 |