1EIX

STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0015949	biological_process	nucleobase-containing small molecule interconversion
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0015949	biological_process	nucleobase-containing small molecule interconversion
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0015949	biological_process	nucleobase-containing small molecule interconversion
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0015949	biological_process	nucleobase-containing small molecule interconversion
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE BMQ A 1301

Chain	Residue
A	ALA20
A	GLN201
A	VAL219
A	GLY221
A	ARG222
A	HOH503
A	HOH506
A	HOH509
A	HOH511
A	HOH512
B	ASP76
A	ASP22
B	ILE77
B	THR80
A	LYS44
A	ASP71
A	LYS73
A	LEU130
A	THR131
A	PRO189
A	ARG192

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE BMQ B 1302

Chain	Residue
A	ASP76
A	ILE77
A	THR80
B	ALA20
B	ASP22
B	LYS44
B	ASP71
B	LYS73
B	LEU130
B	THR131
B	PRO189
B	ARG192
B	GLN201
B	GLY221
B	ARG222
B	HOH523
B	HOH526
B	HOH529
B	HOH531
B	HOH532

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE BMQ C 1303

Chain	Residue
C	ALA20
C	ASP22
C	LYS44
C	ASP71
C	LYS73
C	LEU130
C	THR131
C	PRO189
C	ARG192
C	GLN201
C	VAL219
C	GLY221
C	ARG222
C	HOH543
C	HOH546
C	HOH549
C	HOH551
C	HOH552
D	ASP76
D	ILE77
D	THR80

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE BMQ D 1304

Chain	Residue
C	ASP76
C	ILE77
C	THR80
D	ALA20
D	ASP22
D	LYS44
D	ASP71
D	LYS73
D	LEU130
D	THR131
D	PRO189
D	ARG192
D	GLN201
D	VAL219
D	GLY221
D	ARG222
D	HOH563
D	HOH566
D	HOH569
D	HOH571
D	HOH572

---

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFlDlKfhDIPnTA

Chain	Residue	Details
A	ILE68-ALA81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	64
Details	Binding site: {}

Chain

Residue

Details

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