1EIX
STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE BMQ A 1301 |
| Chain | Residue |
| A | ALA20 |
| A | GLN201 |
| A | VAL219 |
| A | GLY221 |
| A | ARG222 |
| A | HOH503 |
| A | HOH506 |
| A | HOH509 |
| A | HOH511 |
| A | HOH512 |
| B | ASP76 |
| A | ASP22 |
| B | ILE77 |
| B | THR80 |
| A | LYS44 |
| A | ASP71 |
| A | LYS73 |
| A | LEU130 |
| A | THR131 |
| A | PRO189 |
| A | ARG192 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMQ B 1302 |
| Chain | Residue |
| A | ASP76 |
| A | ILE77 |
| A | THR80 |
| B | ALA20 |
| B | ASP22 |
| B | LYS44 |
| B | ASP71 |
| B | LYS73 |
| B | LEU130 |
| B | THR131 |
| B | PRO189 |
| B | ARG192 |
| B | GLN201 |
| B | GLY221 |
| B | ARG222 |
| B | HOH523 |
| B | HOH526 |
| B | HOH529 |
| B | HOH531 |
| B | HOH532 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE BMQ C 1303 |
| Chain | Residue |
| C | ALA20 |
| C | ASP22 |
| C | LYS44 |
| C | ASP71 |
| C | LYS73 |
| C | LEU130 |
| C | THR131 |
| C | PRO189 |
| C | ARG192 |
| C | GLN201 |
| C | VAL219 |
| C | GLY221 |
| C | ARG222 |
| C | HOH543 |
| C | HOH546 |
| C | HOH549 |
| C | HOH551 |
| C | HOH552 |
| D | ASP76 |
| D | ILE77 |
| D | THR80 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE BMQ D 1304 |
| Chain | Residue |
| C | ASP76 |
| C | ILE77 |
| C | THR80 |
| D | ALA20 |
| D | ASP22 |
| D | LYS44 |
| D | ASP71 |
| D | LYS73 |
| D | LEU130 |
| D | THR131 |
| D | PRO189 |
| D | ARG192 |
| D | GLN201 |
| D | VAL219 |
| D | GLY221 |
| D | ARG222 |
| D | HOH563 |
| D | HOH566 |
| D | HOH569 |
| D | HOH571 |
| D | HOH572 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFlDlKfhDIPnTA |
| Chain | Residue | Details |
| A | ILE68-ALA81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | Binding site: {} |
| Chain | Residue | Details |
