1EI9

CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002084	biological_process	protein depalmitoylation
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006897	biological_process	endocytosis
A	0006898	biological_process	receptor-mediated endocytosis
A	0006907	biological_process	pinocytosis
A	0007042	biological_process	lysosomal lumen acidification
A	0007399	biological_process	nervous system development
A	0007420	biological_process	brain development
A	0008021	cellular_component	synaptic vesicle
A	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
A	0015031	biological_process	protein transport
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030424	cellular_component	axon
A	0031579	biological_process	membrane raft organization
A	0043066	biological_process	negative regulation of apoptotic process
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045121	cellular_component	membrane raft
A	0048260	biological_process	positive regulation of receptor-mediated endocytosis
A	0048549	biological_process	positive regulation of pinocytosis
A	0098599	molecular_function	palmitoyl hydrolase activity
A	0120146	molecular_function	sulfatide binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"10781062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P50897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1eh5

Chain	Residue	Details
A	MET41	electrostatic stabiliser
A	SER115	covalently attached, electrostatic stabiliser, proton shuttle (general acid/base)
A	GLN116	electrostatic stabiliser
A	ASP233	electrostatic stabiliser
A	HIS289	electrostatic stabiliser, proton shuttle (general acid/base)