Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | LYS1074 |
| A | ARG1097 |
| A | GLY1303 |
| A | PHE1304 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2 |
| Chain | Residue |
| B | LYS1074 |
| B | ARG1097 |
| B | GLY1303 |
| B | PHE1304 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | ILE1532 |
| A | MET1533 |
| A | ARG1178 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | HOH262 |
| A | SER1044 |
| A | ASP1046 |
| A | LYS1256 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | ARG1175 |
| A | ARG1178 |
| A | GLY1537 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | ARG1319 |
| A | TYR1441 |
| A | ASN1442 |
| A | LEU1443 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 7 |
| Chain | Residue |
| A | HOH135 |
| A | ASN1382 |
| A | ALA1383 |
| A | TRP1412 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 8 |
| Chain | Residue |
| A | ASP1007 |
| A | TYR1116 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 9 |
| Chain | Residue |
| A | ALA1188 |
| B | ARG1175 |
| B | ARG1178 |
| B | MET1533 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 10 |
| Chain | Residue |
| B | SER1044 |
| B | ASP1046 |
| B | LYS1256 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 11 |
| Chain | Residue |
| B | HOH303 |
| B | ARG1162 |
| B | THR1163 |
| B | ILE1164 |
Functional Information from PROSITE/UniProt
| site_id | PS00721 |
| Number of Residues | 11 |
| Details | FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GIKGGAAGGGY |
| Chain | Residue | Details |
| A | GLY1106-TYR1116 | |
| site_id | PS00722 |
| Number of Residues | 12 |
| Details | FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATVRALKmHGG |
| Chain | Residue | Details |
| A | VAL1331-GLY1342 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01543","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 385 |
| Chain | Residue | Details |
| A | LYS1074 | electrostatic stabiliser |
| A | THR1076 | steric role |
| A | ARG1097 | electrostatic stabiliser |
| A | LYS1108 | electrostatic stabiliser |
| A | ALA1276 | electrostatic stabiliser |
| A | PHE1304 | electrostatic stabiliser |
| A | PHE1384 | activator |
| A | TRP1412 | activator |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 385 |
| Chain | Residue | Details |
| B | LYS1074 | electrostatic stabiliser |
| B | THR1076 | steric role |
| B | ARG1097 | electrostatic stabiliser |
| B | LYS1108 | electrostatic stabiliser |
| B | ALA1276 | electrostatic stabiliser |
| B | PHE1304 | electrostatic stabiliser |
| B | PHE1384 | activator |
| B | TRP1412 | activator |
