1EFH
CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004027 | molecular_function | alcohol sulfotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008206 | biological_process | bile acid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030573 | biological_process | bile acid catabolic process |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| A | 0160025 | biological_process | sensory perception of itch |
| B | 0004027 | molecular_function | alcohol sulfotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008203 | biological_process | cholesterol metabolic process |
| B | 0008206 | biological_process | bile acid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030573 | biological_process | bile acid catabolic process |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| B | 0051923 | biological_process | sulfation |
| B | 0160025 | biological_process | sensory perception of itch |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P B 302 |
| Chain | Residue |
| B | LYS44 |
| B | SER218 |
| B | SER219 |
| B | PHE220 |
| B | MET223 |
| B | LEU245 |
| B | LEU246 |
| B | ARG247 |
| B | LYS248 |
| B | GLY249 |
| B | HOH313 |
| B | SER45 |
| B | HOH322 |
| B | HOH338 |
| B | HOH343 |
| B | HOH367 |
| B | GLY46 |
| B | THR47 |
| B | ASN48 |
| B | TRP49 |
| B | ARG121 |
| B | SER129 |
| B | TYR184 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE A3P A 303 |
| Chain | Residue |
| A | LYS44 |
| A | SER45 |
| A | GLY46 |
| A | THR47 |
| A | ASN48 |
| A | TRP49 |
| A | ARG121 |
| A | SER129 |
| A | TYR184 |
| A | SER218 |
| A | SER219 |
| A | PHE220 |
| A | MET223 |
| A | LEU245 |
| A | LEU246 |
| A | ARG247 |
| A | LYS248 |
| A | GLY249 |
| A | HOH324 |
| A | HOH329 |
| A | HOH352 |
| A | HOH370 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11988089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
