1EED

X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004190	molecular_function	aspartic-type endopeptidase activity
P	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0EO P 327

Chain	Residue
P	GLY76
P	ASP77
P	LEU120
P	ASP215
P	GLY217
P	THR218
P	THR219
P	LEU220
P	HOH592
P	HOH600
P	HOH602
P	HOH603
P	ILE7
P	ASP30
P	ASP32
P	GLY34
P	ILE73
P	SER74
P	TYR75

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site_id	CAT
Number of Residues	2
Details	CATALYTIC RESIDUES

Chain	Residue
P	ASP32
P	ASP215

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
P	LEU29-VAL40
P	GLY212-LEU223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	311
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

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