1EE8

CRYSTAL STRUCTURE OF MUTM (FPG) PROTEIN FROM THERMUS THERMOPHILUS HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0016829	molecular_function	lyase activity
A	0019104	molecular_function	DNA N-glycosylase activity
A	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
A	0046872	molecular_function	metal ion binding
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003824	molecular_function	catalytic activity
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
B	0016829	molecular_function	lyase activity
B	0019104	molecular_function	DNA N-glycosylase activity
B	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
B	0046872	molecular_function	metal ion binding
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS238
A	CYS241
A	CYS258
A	CYS261

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS238
B	CYS241
B	CYS258
B	CYS261

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Functional Information from PROSITE/UniProt

site_id	PS01242
Number of Residues	25
Details	ZF_FPG_1 Zinc finger FPG-type signature. Cpa..CGrpVerrvvag....RGthFCptCQ

Chain	Residue	Details
A	CYS238-GLN262

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	ZN_FING: FPG-type

Chain	Residue	Details
A	ALA229-GLY263
B	ALA229-GLY263

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000305

Chain	Residue	Details
A	PRO1
B	PRO1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000305

Chain	Residue	Details
A	GLU2
B	GLU2

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site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: Proton donor; for beta-elimination activity => ECO:0000305

Chain	Residue	Details
A	LYS52
B	LYS52

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site_id	SWS_FT_FI5
Number of Residues	2
Details	ACT_SITE: Proton donor; for delta-elimination activity => ECO:0000305

Chain	Residue	Details
A	ARG253
B	ARG253

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site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS81
A	ARG99
B	HIS81
B	ARG99

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1k82

Chain	Residue	Details
A	GLU2
A	LYS52
A	PRO1
A	ARG253

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1k82

Chain	Residue	Details
B	GLU2
B	LYS52
B	PRO1
B	ARG253

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