Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1860 |
| Chain | Residue |
| A | TRP358 |
| A | VAL420 |
| A | SER428 |
| A | HOH1970 |
| A | HOH2251 |
| A | HOH2278 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 2860 |
| Chain | Residue |
| B | HOH2976 |
| B | GLY188 |
| B | TRP358 |
| B | SER428 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 900 |
| Chain | Residue |
| A | CYS96 |
| A | CYS101 |
| B | CYS96 |
| B | CYS101 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM A 1500 |
| Chain | Residue |
| A | TRP180 |
| A | ARG185 |
| A | CYS186 |
| A | SER228 |
| A | PHE355 |
| A | SER356 |
| A | TRP358 |
| A | GLU363 |
| A | TRP449 |
| A | TYR477 |
| A | NRG1705 |
| A | HOH1961 |
| A | HOH2008 |
| A | HOH2014 |
| A | HOH2038 |
| A | HOH2039 |
| A | HOH2041 |
| A | HOH2097 |
| A | HOH2178 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NRG A 1705 |
| Chain | Residue |
| A | GLN249 |
| A | PRO336 |
| A | SER356 |
| A | GLY357 |
| A | TRP358 |
| A | TYR359 |
| A | GLU363 |
| A | ASN368 |
| A | HEM1500 |
| A | HOH1973 |
| A | HOH2006 |
| A | HOH2105 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CAD A 1950 |
| Chain | Residue |
| A | TRP324 |
| A | CYS384 |
| A | LYS438 |
| A | ARG440 |
| A | GLY441 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM B 2500 |
| Chain | Residue |
| B | TRP180 |
| B | ARG185 |
| B | CYS186 |
| B | SER228 |
| B | PHE355 |
| B | SER356 |
| B | TRP358 |
| B | GLU363 |
| B | TRP449 |
| B | TYR477 |
| B | NRG2705 |
| B | HOH2956 |
| B | HOH2983 |
| B | HOH3001 |
| B | HOH3006 |
| B | HOH3036 |
| B | HOH3145 |
| B | HOH3219 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NRG B 2705 |
| Chain | Residue |
| B | GLN249 |
| B | SER356 |
| B | GLY357 |
| B | TRP358 |
| B | TYR359 |
| B | GLU363 |
| B | ASN368 |
| B | HEM2500 |
| B | HOH2952 |
| B | HOH2958 |
| B | HOH3070 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CAD B 2950 |
| Chain | Residue |
| B | TYR83 |
| B | TRP324 |
| B | CYS384 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1880 |
| Chain | Residue |
| A | VAL263 |
| A | GLY265 |
| A | PRO267 |
| A | ARG287 |
| A | TYR375 |
| A | HOH2016 |
| A | HOH2089 |
| A | HOH2253 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1890 |
| Chain | Residue |
| A | ARG367 |
| A | ALA448 |
| A | TRP449 |
| A | HOH1994 |
| A | HOH2005 |
| A | HOH2041 |
| A | HOH2143 |
| B | TRP447 |
| B | PHE462 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 2880 |
| Chain | Residue |
| B | VAL263 |
| B | GLY265 |
| B | ARG287 |
| B | ARG374 |
| B | TYR375 |
| B | HOH3117 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 2890 |
| Chain | Residue |
| A | PHE462 |
| B | SER104 |
| B | VAL106 |
| B | ALA448 |
| B | TRP449 |
| B | HOH3001 |
| B | HOH3075 |
| B | HOH3159 |
| B | HOH3232 |
| B | HOH3233 |
| B | HOH3234 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG185-TRP192 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASN134 | |
| A | SER139 | |
| B | ASN134 | |
| B | SER139 | |
| Chain | Residue | Details |
| A | ARG142 | |
| B | LYS397 | |
| B | ALA401 | |
| B | LEU406 | |
| A | ARG287 | |
| A | TRP396 | |
| A | LYS397 | |
| A | ALA401 | |
| A | LEU406 | |
| B | ARG142 | |
| B | ARG287 | |
| B | TRP396 | |
| Chain | Residue | Details |
| A | GLY224 | |
| B | GLY224 | |
| Chain | Residue | Details |
| A | GLU154 | |
| B | GLU154 | |
| Chain | Residue | Details |
| A | ARG40 | |
| B | ARG40 | |
| Chain | Residue | Details |
| A | SER53 | |
| A | PRO64 | |
| B | SER53 | |
| B | PRO64 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | CYS186 | |
| A | ARG189 | |
| A | GLU363 | |
| A | TRP358 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | CYS186 | |
| B | ARG189 | |
| B | GLU363 | |
| B | TRP358 | |
