1E9A
Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0043627 | biological_process | response to estrogen |
| A | 0045445 | biological_process | myoblast differentiation |
| A | 0046105 | biological_process | thymidine biosynthetic process |
| A | 0046686 | biological_process | response to cadmium ion |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| A | 0071363 | biological_process | cellular response to growth factor stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | SER20 |
| A | Z5A301 |
| A | HOH2031 |
| A | HOH2152 |
| A | HOH2277 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | HOH2170 |
| A | HOH2170 |
| A | HOH2073 |
| A | HOH2073 |
| A | HOH2168 |
| A | HOH2168 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE Z5A A 301 |
| Chain | Residue |
| A | ALA17 |
| A | GLY18 |
| A | LYS19 |
| A | SER20 |
| A | THR21 |
| A | PHE42 |
| A | ARG45 |
| A | PHE72 |
| A | ARG76 |
| A | ARG97 |
| A | GLY102 |
| A | PHE105 |
| A | ARG143 |
| A | TYR151 |
| A | GLN157 |
| A | LYS182 |
| A | SER183 |
| A | ILE184 |
| A | ARG192 |
| A | MG401 |
| A | HOH2078 |
| A | HOH2152 |
| A | HOH2197 |
| A | HOH2199 |
| A | HOH2277 |
| A | HOH2278 |
| A | HOH2279 |
| A | HOH2280 |
| A | HOH2281 |
| A | HOH2282 |
| A | HOH2283 |
| A | HOH2284 |
| A | HOH2285 |
| A | HOH2287 |
| A | HOH2288 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. VVDRYafSGvAFT |
| Chain | Residue | Details |
| A | VAL94-THR106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3 |
| Chain | Residue | Details |
| A | ARG16 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1 |
| Chain | Residue | Details |
| A | ARG97 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3 |
| Chain | Residue | Details |
| A | LYS182 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1, ECO:0007744|PDB:1NN5 |
| Chain | Residue | Details |
| A | ARG192 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS169 |
