1E7K

Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000245	biological_process	spliceosomal complex assembly
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000451	biological_process	rRNA 2'-O-methylation
A	0000492	biological_process	box C/D snoRNP assembly
A	0001651	cellular_component	dense fibrillar component
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005687	cellular_component	U4 snRNP
A	0005690	cellular_component	U4atac snRNP
A	0005730	cellular_component	nucleolus
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016556	biological_process	mRNA modification
A	0030182	biological_process	neuron differentiation
A	0030490	biological_process	maturation of SSU-rRNA
A	0030515	molecular_function	snoRNA binding
A	0030621	molecular_function	U4 snRNA binding
A	0030622	molecular_function	U4atac snRNA binding
A	0031428	cellular_component	box C/D methylation guide snoRNP complex
A	0032040	cellular_component	small-subunit processome
A	0032991	cellular_component	protein-containing complex
A	0034511	molecular_function	U3 snoRNA binding
A	0034512	molecular_function	box C/D sno(s)RNA binding
A	0042254	biological_process	ribosome biogenesis
A	0042274	biological_process	ribosomal small subunit biogenesis
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0051117	molecular_function	ATPase binding
A	0071001	cellular_component	U4/U6 snRNP
A	0071002	cellular_component	U4atac/U6atac snRNP
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
A	0071011	cellular_component	precatalytic spliceosome
A	0071016	cellular_component	U12-type precatalytic spliceosome
A	1990904	cellular_component	ribonucleoprotein complex
B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
B	0000245	biological_process	spliceosomal complex assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0000451	biological_process	rRNA 2'-O-methylation
B	0000492	biological_process	box C/D snoRNP assembly
B	0001651	cellular_component	dense fibrillar component
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005687	cellular_component	U4 snRNP
B	0005690	cellular_component	U4atac snRNP
B	0005730	cellular_component	nucleolus
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016556	biological_process	mRNA modification
B	0030182	biological_process	neuron differentiation
B	0030490	biological_process	maturation of SSU-rRNA
B	0030515	molecular_function	snoRNA binding
B	0030621	molecular_function	U4 snRNA binding
B	0030622	molecular_function	U4atac snRNA binding
B	0031428	cellular_component	box C/D methylation guide snoRNP complex
B	0032040	cellular_component	small-subunit processome
B	0032991	cellular_component	protein-containing complex
B	0034511	molecular_function	U3 snoRNA binding
B	0034512	molecular_function	box C/D sno(s)RNA binding
B	0042254	biological_process	ribosome biogenesis
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0051117	molecular_function	ATPase binding
B	0071001	cellular_component	U4/U6 snRNP
B	0071002	cellular_component	U4atac/U6atac snRNP
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
B	0071011	cellular_component	precatalytic spliceosome
B	0071016	cellular_component	U12-type precatalytic spliceosome
B	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
A	CYS73-GLY90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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