1E4C

L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant S71Q

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0005829	cellular_component	cytosol
P	0005996	biological_process	monosaccharide metabolic process
P	0006004	biological_process	fucose metabolic process
P	0008270	molecular_function	zinc ion binding
P	0008738	molecular_function	L-fuculose-phosphate aldolase activity
P	0016829	molecular_function	lyase activity
P	0016832	molecular_function	aldehyde-lyase activity
P	0019317	biological_process	fucose catabolic process
P	0019323	biological_process	pentose catabolic process
P	0019568	biological_process	arabinose catabolic process
P	0019571	biological_process	D-arabinose catabolic process
P	0042355	biological_process	L-fucose catabolic process
P	0046872	molecular_function	metal ion binding
P	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 S 301

Chain	Residue
P	TRP74
P	ARG75
P	HOH411
P	HOH479
P	HOH456
P	HOH436

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN S 999

Chain	Residue
P	TYR113
P	HIS155
P	HOH404
P	GLU73
P	HIS92
P	HIS94

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME S 314

Chain	Residue
P	CYS14
P	GLY28
P	ILE45
P	TYR47
P	HOH425

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00987","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299567","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00987","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299567","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Plays a key role in the stabilization of the transition state and positioning the aldehyde component","evidences":[{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1fua

Chain	Residue	Details
P	TYR113
P	GLU73

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fua

Chain	Residue	Details
P	ALA117

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 72

Chain

Residue

Details

---