Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1E3S

Rat brain 3-hydroxyacyl-CoA dehydrogenase binary complex with NADH

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0001540molecular_functionamyloid-beta binding
A0003857molecular_function(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
A0005496molecular_functionsteroid binding
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0006550biological_processL-isoleucine catabolic process
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0006699biological_processbile acid biosynthetic process
A0007005biological_processmitochondrion organization
A0008033biological_processtRNA processing
A0008202biological_processsteroid metabolic process
A0008207biological_processC21-steroid hormone metabolic process
A0008209biological_processandrogen metabolic process
A0008210biological_processestrogen metabolic process
A0008584biological_processmale gonad development
A0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
A0016491molecular_functionoxidoreductase activity
A0018454molecular_functionacetoacetyl-CoA reductase activity
A0030331molecular_functionnuclear estrogen receptor binding
A0030678cellular_componentmitochondrial ribonuclease P complex
A0033327biological_processLeydig cell differentiation
A0042645cellular_componentmitochondrial nucleoid
A0042802molecular_functionidentical protein binding
A0043527cellular_componenttRNA methyltransferase complex
A0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
A0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
A0051287molecular_functionNAD binding
A0051289biological_processprotein homotetramerization
A0062173biological_processbrexanolone metabolic process
A0070901biological_processmitochondrial tRNA methylation
A0097745biological_processmitochondrial tRNA 5'-end processing
A0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
A0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A1990180biological_processmitochondrial tRNA 3'-end processing
B0000049molecular_functiontRNA binding
B0001540molecular_functionamyloid-beta binding
B0003857molecular_function(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
B0005496molecular_functionsteroid binding
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0006550biological_processL-isoleucine catabolic process
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0006699biological_processbile acid biosynthetic process
B0007005biological_processmitochondrion organization
B0008033biological_processtRNA processing
B0008202biological_processsteroid metabolic process
B0008207biological_processC21-steroid hormone metabolic process
B0008209biological_processandrogen metabolic process
B0008210biological_processestrogen metabolic process
B0008584biological_processmale gonad development
B0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
B0016491molecular_functionoxidoreductase activity
B0018454molecular_functionacetoacetyl-CoA reductase activity
B0030331molecular_functionnuclear estrogen receptor binding
B0030678cellular_componentmitochondrial ribonuclease P complex
B0033327biological_processLeydig cell differentiation
B0042645cellular_componentmitochondrial nucleoid
B0042802molecular_functionidentical protein binding
B0043527cellular_componenttRNA methyltransferase complex
B0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
B0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
B0051287molecular_functionNAD binding
B0051289biological_processprotein homotetramerization
B0062173biological_processbrexanolone metabolic process
B0070901biological_processmitochondrial tRNA methylation
B0097745biological_processmitochondrial tRNA 5'-end processing
B0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
B0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B1990180biological_processmitochondrial tRNA 3'-end processing
C0000049molecular_functiontRNA binding
C0001540molecular_functionamyloid-beta binding
C0003857molecular_function(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
C0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
C0005496molecular_functionsteroid binding
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0006550biological_processL-isoleucine catabolic process
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0006699biological_processbile acid biosynthetic process
C0007005biological_processmitochondrion organization
C0008033biological_processtRNA processing
C0008202biological_processsteroid metabolic process
C0008207biological_processC21-steroid hormone metabolic process
C0008209biological_processandrogen metabolic process
C0008210biological_processestrogen metabolic process
C0008584biological_processmale gonad development
C0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
C0016491molecular_functionoxidoreductase activity
C0018454molecular_functionacetoacetyl-CoA reductase activity
C0030331molecular_functionnuclear estrogen receptor binding
C0030678cellular_componentmitochondrial ribonuclease P complex
C0033327biological_processLeydig cell differentiation
C0042645cellular_componentmitochondrial nucleoid
C0042802molecular_functionidentical protein binding
C0043527cellular_componenttRNA methyltransferase complex
C0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
C0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
C0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
C0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
C0051287molecular_functionNAD binding
C0051289biological_processprotein homotetramerization
C0062173biological_processbrexanolone metabolic process
C0070901biological_processmitochondrial tRNA methylation
C0097745biological_processmitochondrial tRNA 5'-end processing
C0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
C0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
C0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
C1990180biological_processmitochondrial tRNA 3'-end processing
D0000049molecular_functiontRNA binding
D0001540molecular_functionamyloid-beta binding
D0003857molecular_function(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
D0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
D0005496molecular_functionsteroid binding
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0006550biological_processL-isoleucine catabolic process
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006635biological_processfatty acid beta-oxidation
D0006699biological_processbile acid biosynthetic process
D0007005biological_processmitochondrion organization
D0008033biological_processtRNA processing
D0008202biological_processsteroid metabolic process
D0008207biological_processC21-steroid hormone metabolic process
D0008209biological_processandrogen metabolic process
D0008210biological_processestrogen metabolic process
D0008584biological_processmale gonad development
D0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
D0016491molecular_functionoxidoreductase activity
D0018454molecular_functionacetoacetyl-CoA reductase activity
D0030331molecular_functionnuclear estrogen receptor binding
D0030678cellular_componentmitochondrial ribonuclease P complex
D0033327biological_processLeydig cell differentiation
D0042645cellular_componentmitochondrial nucleoid
D0042802molecular_functionidentical protein binding
D0043527cellular_componenttRNA methyltransferase complex
D0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
D0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
D0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
D0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
D0051287molecular_functionNAD binding
D0051289biological_processprotein homotetramerization
D0062173biological_processbrexanolone metabolic process
D0070901biological_processmitochondrial tRNA methylation
D0097745biological_processmitochondrial tRNA 5'-end processing
D0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
D0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
D0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
D1990180biological_processmitochondrial tRNA 3'-end processing
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE NAD A 301
ChainResidue
AGLY17
AALA92
ATHR153
AALA154
ATYR168
ALYS172
APRO198
AGLY199
APHE201
ATHR203
APRO204
ASER20
AHOH2037
AHOH2107
AHOH2108
AHOH2109
AGLY21
ALEU22
AASP41
AALA63
AASN64
AVAL65
ACYS91
site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NAD B 301
ChainResidue
BGLY17
BSER20
BGLY21
BLEU22
BASP41
BVAL42
BALA63
BASN64
BVAL65
BCYS91
BALA92
BGLY93
BTHR153
BALA154
BTYR168
BLYS172
BPRO198
BGLY199
BPHE201
BTHR203
BPRO204
BHOH2127
BHOH2128
BHOH2129
BHOH2130
site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAD C 301
ChainResidue
CGLY17
CSER20
CGLY21
CLEU22
CASP41
CALA63
CASN64
CVAL65
CCYS91
CALA92
CGLY93
CTHR153
CALA154
CTYR168
CLYS172
CPRO198
CGLY199
CPHE201
CTHR203
CPRO204
CHOH2047
CHOH2122
CHOH2123
CHOH2124
site_idAC4
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAD D 301
ChainResidue
DGLY17
DSER20
DGLY21
DLEU22
DASP41
DALA63
DASN64
DVAL65
DCYS91
DALA92
DGLY93
DTHR153
DALA154
DTYR168
DLYS172
DGLY199
DPHE201
DTHR203
DPRO204
DHOH2007
DHOH2126
DHOH2127
DHOH2128
DHOH2129
Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvaafegqvgQaaYSASKGGIvGMTlPIA
ChainResidueDetails
ASER155-ALA183
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11023795","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q99714","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11023795","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08756","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08756","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
APHE159
site_idCSA10
Number of Residues4
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
BLYS172
BSER155
BASN121
BTYR168
site_idCSA11
Number of Residues4
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
CLYS172
CSER155
CASN121
CTYR168
site_idCSA12
Number of Residues4
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
DLYS172
DSER155
DASN121
DTYR168
site_idCSA13
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
ALYS172
AGLN165
site_idCSA14
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
BLYS172
BGLN165
site_idCSA15
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
CLYS172
CGLN165
site_idCSA16
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
DLYS172
DGLN165
site_idCSA17
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
ALYS172
ATYR168
site_idCSA18
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
BLYS172
BTYR168
site_idCSA19
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
CLYS172
CTYR168
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
BPHE159
site_idCSA20
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
DLYS172
DTYR168
site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
CPHE159
site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
DPHE159
site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
ALYS172
ASER155
ATYR168
site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
BLYS172
BSER155
BTYR168
site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
CLYS172
CSER155
CTYR168
site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
DLYS172
DSER155
DTYR168
site_idCSA9
Number of Residues4
DetailsAnnotated By Reference To The Literature 1eq2
ChainResidueDetails
ALYS172
ASER155
AASN121
ATYR168

243911

PDB entries from 2025-10-29

PDB statisticsPDBj update infoContact PDBjnumon