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1E3I

Mouse class II alcohol dehydrogenase complex with NADH and inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001523biological_processretinoid metabolic process
A0003960molecular_functionquinone reductase (NADPH) activity
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0004032molecular_functionaldose reductase (NADPH) activity
A0004745molecular_functionall-trans-retinol dehydrogenase (NAD+) activity
A0005503molecular_functionall-trans retinal binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006066biological_processalcohol metabolic process
A0006067biological_processethanol metabolic process
A0006081biological_processaldehyde metabolic process
A0006629biological_processlipid metabolic process
A0008270molecular_functionzinc ion binding
A0010430biological_processfatty acid omega-oxidation
A0016491molecular_functionoxidoreductase activity
A0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
A0019841molecular_functionretinol binding
A0042572biological_processretinol metabolic process
A0044282biological_processsmall molecule catabolic process
A0046164biological_processalcohol catabolic process
A0046294biological_processformaldehyde catabolic process
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
A0051903molecular_functionS-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
A1901661biological_processquinone metabolic process
B0001523biological_processretinoid metabolic process
B0003960molecular_functionquinone reductase (NADPH) activity
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0004032molecular_functionaldose reductase (NADPH) activity
B0004745molecular_functionall-trans-retinol dehydrogenase (NAD+) activity
B0005503molecular_functionall-trans retinal binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006066biological_processalcohol metabolic process
B0006067biological_processethanol metabolic process
B0006081biological_processaldehyde metabolic process
B0006629biological_processlipid metabolic process
B0008270molecular_functionzinc ion binding
B0010430biological_processfatty acid omega-oxidation
B0016491molecular_functionoxidoreductase activity
B0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
B0019841molecular_functionretinol binding
B0042572biological_processretinol metabolic process
B0044282biological_processsmall molecule catabolic process
B0046164biological_processalcohol catabolic process
B0046294biological_processformaldehyde catabolic process
B0046872molecular_functionmetal ion binding
B0051287molecular_functionNAD binding
B0051903molecular_functionS-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
B1901661biological_processquinone metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 380
ChainResidue
ACYS46
AHIS67
ACYS178
ACXF378

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 381
ChainResidue
ACYS97
ACYS100
ACYS103
ACYS111
AGLY112

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 380
ChainResidue
BCYS46
BHIS67
BCYS178
BCXF378

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 381
ChainResidue
BCYS97
BCYS100
BCYS103
BCYS111
BGLY112

site_idAC5
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAI A 377
ChainResidue
APRO47
ATHR48
ACYS178
ASER182
AGLY203
AGLY205
ACYS206
AVAL207
AASP227
AILE228
ALYS232
ACYS272
ATHR275
ATHR278
AVAL296
AGLY297
ATHR319
APHE320
APHE321
AARG371
ACXF378
AHOH2136
AHOH2179
AHOH2180
AHOH2184
AHOH2185
AHOH2186
BASP362

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CXF A 378
ChainResidue
ACYS46
ATHR48
AHIS67
APHE93
AMET145
ACYS178
ANAI377
AZN380

site_idAC7
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAI B 377
ChainResidue
BPRO47
BTHR48
BCYS178
BSER182
BGLY203
BGLY205
BCYS206
BVAL207
BASP227
BILE228
BLYS232
BCYS272
BTHR278
BVAL296
BGLY297
BTHR319
BPHE320
BPHE321
BARG371
BCXF378
BHOH2096
BHOH2103
BHOH2132
BHOH2134
BHOH2176
BHOH2177
BHOH2180
BHOH2181
BHOH2182
BHOH2183

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CXF B 378
ChainResidue
BCYS46
BTHR48
BHIS67
BPHE93
BCYS178
BNAI377
BZN380

Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEcAGIvesvGpgV
ChainResidueDetails
AGLY66-VAL80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues26
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10970744","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
ATHR48
APRO47

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
BTHR48
BPRO47

site_idMCSA1
Number of Residues6
DetailsM-CSA 500
ChainResidueDetails
ACYS46metal ligand
APRO47steric role
ATHR48proton shuttle (general acid/base)
AHIS67metal ligand
ACYS178metal ligand
ASER182proton shuttle (general acid/base)

site_idMCSA2
Number of Residues6
DetailsM-CSA 500
ChainResidueDetails
BCYS46metal ligand
BPRO47steric role
BTHR48proton shuttle (general acid/base)
BHIS67metal ligand
BCYS178metal ligand
BSER182proton shuttle (general acid/base)

239803

PDB entries from 2025-08-06

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