1E3E
Mouse class II alcohol dehydrogenase complex with NADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0003960 | molecular_function | NADPH:quinone reductase activity |
| A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0004745 | molecular_function | all-trans-retinol dehydrogenase (NAD+) activity |
| A | 0005503 | molecular_function | all-trans retinal binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006066 | biological_process | alcohol metabolic process |
| A | 0006067 | biological_process | ethanol metabolic process |
| A | 0006081 | biological_process | aldehyde metabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0010430 | biological_process | fatty acid omega-oxidation |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| A | 0019841 | molecular_function | retinol binding |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0044282 | biological_process | small molecule catabolic process |
| A | 0046164 | biological_process | alcohol catabolic process |
| A | 0046294 | biological_process | formaldehyde catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0051903 | molecular_function | S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity |
| A | 1901661 | biological_process | quinone metabolic process |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0003960 | molecular_function | NADPH:quinone reductase activity |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0004745 | molecular_function | all-trans-retinol dehydrogenase (NAD+) activity |
| B | 0005503 | molecular_function | all-trans retinal binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006066 | biological_process | alcohol metabolic process |
| B | 0006067 | biological_process | ethanol metabolic process |
| B | 0006081 | biological_process | aldehyde metabolic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010430 | biological_process | fatty acid omega-oxidation |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| B | 0019841 | molecular_function | retinol binding |
| B | 0042572 | biological_process | retinol metabolic process |
| B | 0044282 | biological_process | small molecule catabolic process |
| B | 0046164 | biological_process | alcohol catabolic process |
| B | 0046294 | biological_process | formaldehyde catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0051903 | molecular_function | S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity |
| B | 1901661 | biological_process | quinone metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 378 |
| Chain | Residue |
| A | CYS46 |
| A | HIS67 |
| A | CYS178 |
| A | HOH2222 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 379 |
| Chain | Residue |
| A | CYS97 |
| A | CYS100 |
| A | CYS103 |
| A | CYS111 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 378 |
| Chain | Residue |
| B | HIS67 |
| B | CYS178 |
| B | HOH2280 |
| B | CYS46 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 379 |
| Chain | Residue |
| B | CYS97 |
| B | LYS98 |
| B | CYS100 |
| B | CYS103 |
| B | CYS111 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAI A 377 |
| Chain | Residue |
| A | THR48 |
| A | SER182 |
| A | GLY203 |
| A | GLY205 |
| A | CYS206 |
| A | VAL207 |
| A | ASP227 |
| A | CYS272 |
| A | THR278 |
| A | VAL296 |
| A | GLY297 |
| A | THR319 |
| A | PHE320 |
| A | PHE321 |
| A | ARG371 |
| A | HOH2151 |
| A | HOH2171 |
| A | HOH2217 |
| A | HOH2218 |
| A | HOH2219 |
| A | HOH2220 |
| A | HOH2221 |
| B | ASP362 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAI B 377 |
| Chain | Residue |
| B | PRO47 |
| B | THR48 |
| B | SER182 |
| B | GLY203 |
| B | GLY205 |
| B | CYS206 |
| B | VAL207 |
| B | ASP227 |
| B | ILE228 |
| B | LYS232 |
| B | CYS272 |
| B | THR278 |
| B | VAL296 |
| B | GLY297 |
| B | THR319 |
| B | PHE320 |
| B | PHE321 |
| B | ARG371 |
| B | HOH2163 |
| B | HOH2267 |
| B | HOH2273 |
| B | HOH2274 |
| B | HOH2275 |
| B | HOH2276 |
| B | HOH2277 |
| B | HOH2278 |
| B | HOH2279 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEcAGIvesvGpgV |
| Chain | Residue | Details |
| A | GLY66-VAL80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | CYS46 | |
| B | CYS97 | |
| B | CYS100 | |
| B | CYS103 | |
| B | CYS111 | |
| B | CYS178 | |
| A | HIS67 | |
| A | CYS97 | |
| A | CYS100 | |
| A | CYS103 | |
| A | CYS111 | |
| A | CYS178 | |
| B | CYS46 | |
| B | HIS67 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10970744 |
| Chain | Residue | Details |
| A | THR48 | |
| B | ASP227 | |
| B | LYS232 | |
| B | VAL296 | |
| B | THR319 | |
| B | ARG371 | |
| A | GLY203 | |
| A | ASP227 | |
| A | LYS232 | |
| A | VAL296 | |
| A | THR319 | |
| A | ARG371 | |
| B | THR48 | |
| B | GLY203 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| A | THR48 | |
| A | PRO47 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| B | THR48 | |
| B | PRO47 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 500 |
| Chain | Residue | Details |
| A | CYS46 | metal ligand |
| A | PRO47 | steric role |
| A | THR48 | proton shuttle (general acid/base) |
| A | HIS67 | metal ligand |
| A | CYS178 | metal ligand |
| A | SER182 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 500 |
| Chain | Residue | Details |
| B | CYS46 | metal ligand |
| B | PRO47 | steric role |
| B | THR48 | proton shuttle (general acid/base) |
| B | HIS67 | metal ligand |
| B | CYS178 | metal ligand |
| B | SER182 | proton shuttle (general acid/base) |
